ArticleMolecular and cellular biology2003
CtBP-independent repression in the Drosophila embryo.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases.Human molecular genetics · 2024Article
- Deciphering enhancer sequence using thermodynamics-based models and convolutional neural networks.Nucleic acids research · 2021Article
- Molecular networks of the FOXP2 transcription factor in the brain.EMBO reports · 2021Review
- The effect of non-coding DNA variations on P53 and cMYC competitive inhibition at cis-overlapping motifs.Human molecular genetics · 2016Article
- CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA.Journal of cellular biochemistry · 2010Article
- Evolutionary mirages: selection on binding site composition creates the illusion of conserved grammars in Drosophila enhancers.PLoS genetics · 2010Article
- Modeling the dynamics of transcriptional gene regulatory networks for animal development.Developmental biology · 2009Review
- Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.Development genes and evolution · 2007Article
- Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos.PLoS biology · 2007Article
- An eh1-like motif in odd-skipped mediates recruitment of Groucho and repression in vivo.Molecular and cellular biology · 2005Article
- cis-regulatory logic of short-range transcriptional repression in Drosophila melanogaster.Molecular and cellular biology · 2005Article
- CtBP contributes quantitatively to Knirps repression activity in an NAD binding-dependent manner.Molecular and cellular biology · 2004Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
There are three mechanisms of transcriptional repression in eukaryotes. The first is quenching, whereby repressors and activators co-occupy closely linked sites and then the repressor inhibits adjacent activators. The second is direct repression, in which repressors block the function of the core transcription complex. The third is competition, in which repressors compete with activators for a common DNA-binding site. Previous studies have shown that the Drosophila melanogaster CtBP corepressor (dCtBP) is essential for the quenching activity of three short-range sequence-specific repressors in the early Drosophila embryo: Krüppel, Knirps, and Snail. Here we demonstrate that dCtBP is dispensable for target enhancers that contain overlapping activator and repressor binding sites. However, it is essential when Krüppel and Knirps repressor sites do not overlap activator sites but are instead located adjacent to either activators or the core promoter. These findings provide evidence that competition is distinct from quenching and direct repression. Quenching and direct repression depend on dCtBP, whereas competition does not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.