ArticleMolecular and cellular biology2003
Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 103 citations in OpenAlex.
- Article
- Transcription factor TFE3 enhances cell cycle and cancer progression by binding to the hTERT promoter.Cancer communications (London, England) · 2021Article
- Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells.Communications biology · 2019Article
- An alternatively spliced form affecting the Marked Box domain of Drosophila E2F1 is required for proper cell cycle regulation.PLoS genetics · 2018Article
- TFE3 regulates renal adenocarcinoma cell proliferation via activation of the mTOR pathway.Molecular medicine reports · 2017Article
- ASPL-TFE3 Oncoprotein Regulates Cell Cycle Progression and Induces Cellular Senescence by Up-Regulating p21.Neoplasia (New York, N.Y.) · 2016Article
- Article
- MYC and metabolism on the path to cancer.Seminars in cell & developmental biology · 2015Review
- Transcriptional control of stem cell fate by E2Fs and pocket proteins.Frontiers in genetics · 2015Review
- E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.PloS one · 2015Article
- Identification of B cells as a major site for cyprinid herpesvirus 3 latency.Journal of virology · 2014Article
- AtSKIP functions as a mediator between cytokinin and light signaling pathway in Arabidopsis thaliana.Plant cell reports · 2014Article
- Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain.Journal of molecular biology · 2014Article
- Article
- The nuclear protein ALY binds to and modulates the activity of transcription factor E2F2.Molecular & cellular proteomics : MCP · 2013Article
- Spatiotemporal expression of SKIP after rat sciatic nerve crush.Neurochemical research · 2013Article
- Deriving transcriptional programs and functional processes from gene expression databases.Bioinformatics (Oxford, England) · 2012Article
- E2F6 associates with BRG1 in transcriptional regulation.PloS one · 2012Article
- YY1 regulates melanocyte development and function by cooperating with MITF.PLoS genetics · 2012Article
- Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targets.Cell cycle (Georgetown, Tex.) · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various studies have demonstrated a role for E2F proteins in the control of transcription of genes involved in DNA replication, cell cycle progression, and cell fate determination. Although it is clear that the functions of the E2F proteins overlap, there is also evidence for specific roles for individual E2F proteins in the control of apoptosis and cell proliferation. Investigating protein interactions that might provide a mechanistic basis for the specificity of E2F function, we identified the E-box binding factor TFE3 as an E2F3-specific partner. We also show that this interaction is dependent on the marked box domain of E2F3. We provide evidence for a role for TFE3 in the synergistic activation of the p68 subunit gene of DNA polymerase alpha together with E2F3, again dependent on the E2F3 marked box domain. Chromatin immunoprecipitation assays showed that TFE3 and E2F3 were bound to the p68 promoter in vivo and that the interaction of either E2F3 or TFE3 with the promoter was facilitated by the presence of both proteins. In contrast, neither E2F1 nor E2F2 interacted with the p68 promoter under these conditions. We propose that the physical interaction of TFE3 and E2F3 facilitates transcriptional activation of the p68 gene and provides strong evidence for the specificity of E2F function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.