ArticleOral oncology2003
Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype.
Article in Oral oncology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer.PloS one · 2015Pooled it
- Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis.PloS one · 2011Pooled it
- Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.Genetics in medicine : official journal of the American College of Medical Genetics · 2008Pooled it
- Pharmacogenomics with red cells: a model to study protein variants of drug transporter genes.Vox sanguinis · 2021Review
- Investigation of the Association between Genetic Polymorphism of Microsomal Epoxide Hydrolase and Primary Brain Tumor Incidence.Molecular biology international · 2013Article
- Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium.Cancer causes & control : CCC · 2012Article
- Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.Frontiers in oncology · 2011Article
- Review of studies on metabolic genes and cancer in populations of African descent.Genetics in medicine : official journal of the American College of Medical Genetics · 2010Review
- An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines.Molecular biology reports · 2009Article
- CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study.Journal of oncology · 2008Article
- Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.Neuro-oncology · 2006Article
- Genetic analysis of microsomal epoxide hydrolase gene and its association with lung cancer risk.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2005Article
- Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD.International journal of molecular medicine · 2005Article
- Functional analysis of human microsomal epoxide hydrolase genetic variants.Chemico-biological interactions · 2004Article
- Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort.BMJ (Clinical research ed.) · 2004Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The human microsomal epoxide hydrolase (EH) gene contains polymorphic alleles which are associated with altered EH activity and may be linked to increased risk for tobacco-related cancers. The objective was to examine the role of EH polymorphisms in orolaryngeal cancer risk. The prevalence of the EH codons 113 and 139 polymorphisms were examined in 81 African American and 142 Caucasian incident orolaryngeal cancer patients and 335 controls frequency-matched on age, sex, and race. In Caucasians, a significant risk increase was observed for subjects with the EH(113Tyr) variant (OR=2.1, 95% CI=1.1-4.0) and predicted high-activity EH genotypes in heavy-smokers (>or=35 pack-years; OR=3.4, 95% CI=1.2-9.6). A significant association between predicted high EH activity genotypes and orolaryngeal cancer risk was observed in Caucasian subjects with the GSTM1 null (OR=3.5, 95% CI=1.3-9.3) but not GSTM [+] (OR=0.9, 95%CI=0.4-2.1) genotype. These results suggest that EH polymorphisms play an important role in risk for orolaryngeal cancer in Caucasians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.