ArticleDevelopment genes and evolution2003
The role of GlsA in the evolution of asymmetric cell division in the green alga Volvox carteri.
Article in Development genes and evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 28 citations in OpenAlex.
- Functional analysis of regA paralog rlsD in Volvox carteri.The Plant journal : for cell and molecular biology · 2024Article
- Gene loss during a transition to multicellularity.Scientific reports · 2023Article
- The Curious Case of Multicellularity in the Volvocine Algae.Frontiers in genetics · 2022Review
- Whole transcriptome RNA-Seq analysis reveals extensive cell type-specific compartmentalization in Volvox carteri.BMC biology · 2017Article
- Volvox: A simple algal model for embryogenesis, morphogenesis and cellular differentiation.Developmental biology · 2016Review
- Origins of multicellular complexity: Volvox and the volvocine algae.Molecular ecology · 2016Article
- Green algae and the origins of multicellularity in the plant kingdom.Cold Spring Harbor perspectives in biology · 2014Review
- Evolution of reproductive development in the volvocine algae.Sexual plant reproduction · 2011Review
- Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri.Science (New York, N.Y.) · 2010Article
- Control of apoptosis by asymmetric cell division.PLoS biology · 2008Article
- Maintenance DNA methyltransferase (Met1) and silencing of CpG-methylated foreign DNA in Volvox carteri.Plant molecular biology · 2007Article
- Orthologs and paralogs of regA, a master cell-type regulatory gene in Volvox carteri.Current genetics · 2006Article
- One of the main forces that advance all fields of scientific inquiry is the establishment of unifying principles.Development genes and evolution · 2004Article
- Potential impact of gene regulatory mechanisms on the evolution of multicellularity in the volvocine algae.Communicative & integrative biologyArticle
- Genomics of Volvocine Algae.Advances in botanical researchArticle
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
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Abstract
Volvox carteri, a green alga in the order Volvocales, contains two completely differentiated cell types, small motile somatic cells and large reproductive cells called gonidia, that are set apart from each other during embryogenesis by a series of visibly asymmetric cell divisions. Mutational analysis has revealed a class of genes (gonidialess, gls) that are required specifically for asymmetric divisions in V. carteri, but that are dispensable for symmetric divisions. Previously we cloned one of these genes, glsA, and showed that it encodes a chaperone-like protein (GlsA) that has close orthologs in a diverse set of eukaryotes, ranging from fungi to vertebrates and higher plants. In the present study we set out to explore the role of glsA in the evolution of asymmetric division in the volvocine algae by cloning and characterizing a glsA ortholog from one of the simplest members of the group, Chlamydomonas reinhardtii, which does not undergo asymmetric divisions. This ortholog (which we have named gar1, for glsA related) is predicted to encode a protein that is 70% identical to GlsA overall, and that is most closely related to GlsA in the same domains that are most highly conserved between GlsA and its other known orthologs. We report that a gar1 transgene fully complements the glsA mutation in V. carteri, a result that suggests that asymmetric division probably arose through the modification of a gene whose product interacts with GlsA, but not through a modification of glsA itself.
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