ArticleParasitology research2003
Molecular cloning and characterization of an SRCAP chromatin remodeling homologue in Toxoplasma gondii.
Article in Parasitology research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Toxoplasma gondii chromatin remodeler SWI/SNF controls parasite division and gene expression.Nature communications · 2025Article
- SPARK regulates AGC kinases central to theeLife · 2024Article
- SPARK regulates AGC kinases central to thebioRxiv : the preprint server for biology · 2024Article
- Peculiarities ofInternational journal of molecular sciences · 2021Review
- Comparative genomic analysis of the principalPeerJ · 2020Article
- A Comparison of Stage Conversion in the Coccidian ApicomplexansFrontiers in cellular and infection microbiology · 2020Review
- A latent ability to persist: differentiation in Toxoplasma gondii.Cellular and molecular life sciences : CMLS · 2018Review
- An in silico pipeline to filter the Toxoplasma gondii proteome for proteins that could traffic to the host cell nucleus and influence host cell epigenetic regulation.Memorias do Instituto Oswaldo Cruz · 2018Article
- Mechanisms of Toxoplasma gondii persistence and latency.FEMS microbiology reviews · 2012Review
- A decade of epigenetic research in Toxoplasma gondii.Molecular and biochemical parasitology · 2010Review
- Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review.Memorias do Instituto Oswaldo Cruz · 2009Review
- Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii.Eukaryotic cell · 2006Article
- Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii.Molecular and cellular biology · 2005Article
- MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii.Eukaryotic cell · 2005Article
- Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.Molecular and cellular biology · 2005Article
- Identification of proteins interacting with Toxoplasma SRCAP by yeast two-hybrid screening.Parasitology research · 2005Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified and mapped a gene in Toxoplasma gondii that encodes a homologue of SRCAP (Snf2-related CBP activator protein), a member of the SNF/SWI family of chromatin remodeling factors. The genomic locus (TgSRCAP) is present as a single copy and contains 16 introns. The predicted cDNA contains an open reading frame of 8,775 bp and encodes a protein of 2,924 amino acids. We have identified additional SRCAP-like sequences in Apicomplexa for comparison by screening genomic databases. An analysis of SRCAP homologues between species reveals signature features that may be indicative of SRCAP members. Expression of mRNA encoding TgSRCAP is upregulated when tachyzoite (invasive form) parasites are induced to differentiate into bradyzoites (encysted form) in vitro. Recombinant TgSRCAP protein is functionally equivalent to the human homologue, being capable of increasing transcription mediated by CREB.
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