ArticleProceedings of the National Academy of Sciences of the United States of America2003
Exponential growth by cross-catalytic cleavage of deoxyribozymogens.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 80 citations in OpenAlex.
- Spatially Localized Entropy-Driven Evolution of Nucleic Acid-Based Constitutional Dynamic Networks for Intracellular Imaging and Spatiotemporal Programmable Gene Therapy.Journal of the American Chemical Society · 2024Article
- Synthetic DNA applications in information technology.Nature communications · 2022Review
- A proteinase-free DNA replication machinery for in vitro and in vivo amplified MicroRNA imaging.Nucleic acids research · 2020Article
- Sensitive Detection of Nucleic Acids Using Subzyme Feedback Cascades.Molecules (Basel, Switzerland) · 2020Article
- Litters of self-replicating origami cross-tiles.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mathematical modeling reveals spontaneous emergence of self-replication in chemical reaction systems.The Journal of biological chemistry · 2018Article
- Construction of an autonomously concatenated hybridization chain reaction for signal amplification and intracellular imaging.Chemical science · 2018Article
- DNA Nanotweezers with Hydrolytic Activity for Enzyme-Free and Sensitive Detection of Fusion Gene via Logic Operation.Journal of analytical methods in chemistry · 2018Article
- Exponential growth and selection in self-replicating materials from DNA origami rafts.Nature materials · 2017Article
- Emergent Behaviors in Kinetically Controlled Dynamic Self-Assembly of Synthetic Molecular Systems.ACS omega · 2016Article
- Programming a topologically constrained DNA nanostructure into a sensor.Nature communications · 2016Article
- DNA cross-triggered cascading self-amplification artificial biochemical circuit.Chemical science · 2015Article
- Programmable chemical controllers made from DNA.Nature nanotechnology · 2013Article
- Article
- Expanding the rule set of DNA circuitry with associative toehold activation.Journal of the American Chemical Society · 2012Article
- Rational, modular adaptation of enzyme-free DNA circuits to multiple detection methods.Nucleic acids research · 2011Article
- RNA-cleaving deoxyribozyme sensor for nucleic acid analysis: the limit of detection.Chembiochem : a European journal of chemical biology · 2010Article
- Nucleic acid detection using MNAzymes.Chemistry & biology · 2010Article
- Beyond allostery: Catalytic regulation of a deoxyribozyme through an entropy-driven DNA amplifier.Journal of systems chemistry · 2010Article
- Biocomputers: from test tubes to live cells.Molecular bioSystems · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have designed an autocatalytic cycle based on the highly efficient 10-23 RNA-cleaving deoxyribozyme that is capable of exponential amplification of catalysis. In this system, complementary 10-23 variants were inactivated by circularization, creating deoxyribozymogens. Upon linearization, the enzymes can act on their complements, creating a cascade in which linearized species accumulate exponentially. Seeding the system with a pool of linear catalysts resulted not only in amplification of function but in sequence selection and represents an in vitro selection experiment conducted in the absence of any protein enzymes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.