ArticleProceedings of the National Academy of Sciences of the United States of America2003
Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- Inferring archaic introgression from hominin genetic data.Evolutionary anthropology · 2021Review
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- Archaeogenetics in evolutionary medicine.Journal of molecular medicine (Berlin, Germany) · 2016Review
- Introduction. Ancient DNA: the first three decades.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Human Dispersal Out of Africa: A Lasting Debate.Evolutionary bioinformatics online · 2015Review
- Fine Dissection of Human Mitochondrial DNA Haplogroup HV Lineages Reveals Paleolithic Signatures from European Glacial Refugia.PloS one · 2015Article
- When the waves of European Neolithization met: first paleogenetic evidence from early farmers in the southern Paris Basin.PloS one · 2015Article
- Aspects of ancient mitochondrial DNA analysis in different populations for understanding human evolution.Balkan journal of medical genetics : BJMG · 2014Review
- Article
- Ancient DNA reveals key stages in the formation of central European mitochondrial genetic diversity.Science (New York, N.Y.) · 2013Article
- Ancestry of modern Europeans: contributions of ancient DNA.Cellular and molecular life sciences : CMLS · 2013Review
- Possible interbreeding in late Italian Neanderthals? New data from the Mezzena jaw (Monti Lessini, Verona, Italy).PloS one · 2013Article
- Monitoring DNA contamination in handled vs. directly excavated ancient human skeletal remains.PloS one · 2013Article
- The Mountain Meadows Massacre and "poisoned springs": scientific testing of the more recent, anthrax theory.International journal of legal medicine · 2013Article
- Ancient DNA studies: new perspectives on old samples.Genetics, selection, evolution : GSE · 2012Review
- Origin and diet of the prehistoric hunter-gatherers on the mediterranean island of Favignana (Ègadi Islands, Sicily).PloS one · 2012Article
- To clone or not to clone: method analysis for retrieving consensus sequences in ancient DNA samples.PloS one · 2011Article
- Ancient DNA from European early neolithic farmers reveals their near eastern affinities.PLoS biology · 2010Article
- Preferential access to genetic information from endogenous hominin ancient DNA and accurate quantitative SNP-typing via SPEX.Nucleic acids research · 2010Article
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11 authors.
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Abstract
During the late Pleistocene, early anatomically modern humans coexisted in Europe with the anatomically archaic Neandertals for some thousand years. Under the recent variants of the multiregional model of human evolution, modern and archaic forms were different but related populations within a single evolving species, and both have contributed to the gene pool of current humans. Conversely, the Out-of-Africa model considers the transition between Neandertals and anatomically modern humans as the result of a demographic replacement, and hence it predicts a genetic discontinuity between them. Following the most stringent current standards for validation of ancient DNA sequences, we typed the mtDNA hypervariable region I of two anatomically modern Homo sapiens sapiens individuals of the Cro-Magnon type dated at about 23 and 25 thousand years ago. Here we show that the mtDNAs of these individuals fall well within the range of variation of today's humans, but differ sharply from the available sequences of the chronologically closer Neandertals. This discontinuity is difficult to reconcile with the hypothesis that both Neandertals and early anatomically modern humans contributed to the current European gene pool.
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