ArticleJournal of virology2003
Unique pattern of convergent envelope evolution in simian immunodeficiency virus-infected rapid progressor macaques: association with CD4-independent usage of CCR5.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Recognition of Apoptotic Cells by Viruses and Cytolytic Lymphocytes: Target Selection in the Fog of War.Viral immunology · 2020Article
- Article
- Emergence of CD4 independence envelopes and astrocyte infection in R5 simian-human immunodeficiency virus model of encephalitis.Journal of virology · 2014Article
- CKR-L3, a deletion version CCR6-isoform shows coreceptor-activity for limited human and simian immunodeficiency viruses.BMC infectious diseases · 2014Article
- CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo.Journal of virology · 2013Article
- CCR6 functions as a new coreceptor for limited primary human and simian immunodeficiency viruses.PloS one · 2013Article
- Acquisition of CD4-dependence by CD4-independent SIV passaged in human peripheral blood mononuclear cells.Retrovirology · 2012Article
- Effects of stabilization of the gp41 cytoplasmic domain on fusion activity and infectivity of SIVmac239.AIDS research and human retroviruses · 2011Article
- Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies.Journal of translational medicine · 2011Review
- Fitness disadvantage of transitional intermediates contributes to dynamic change in the infecting-virus population during coreceptor switch in R5 simian/human immunodeficiency virus-infected macaques.Journal of virology · 2010Article
- Accelerated evolution of SIV env within the cerebral compartment in the setting of morphine-dependent rapid disease progression.Virology · 2010Article
- Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes.Journal of virology · 2009Article
- Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies.PLoS pathogens · 2009Article
- Adaptive evolution of simian immunodeficiency viruses isolated from 2 conventional-progressor macaques with encephalitis.The Journal of infectious diseases · 2008Article
- Persistent transcription of a nonintegrating mutant of simian immunodeficiency virus in rhesus macrophages.Virology · 2008Article
- A rapid progressor-specific variant clone of simian immunodeficiency virus replicates efficiently in vivo only in the absence of immune responses.Journal of virology · 2007Article
- CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates.Retrovirology · 2007Article
- Mucosal innate immune response associated with a timely humoral immune response and slower disease progression after oral transmission of simian immunodeficiency virus to rhesus macaques.Journal of virology · 2007Article
- Unique pathology in simian immunodeficiency virus-infected rapid progressor macaques is consistent with a pathogenesis distinct from that of classical AIDS.Journal of virology · 2007Article
- Simian immunodeficiency virus envelope compartmentalizes in brain regions independent of neuropathology.Journal of neurovirology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The rate of disease development in simian immunodeficiency virus (SIV) infection of macaques varies considerably among individual macaques. While the majority of macaques inoculated with pathogenic SIV develop AIDS within a period of 1 to 2 years, a minority exhibit a rapid disease course characterized by absence or transience of humoral and cellular immune responses and high levels of virus replication with widespread dissemination of SIV in macrophages and multinucleated giant cells. The goal of this study was to examine viral evolution in three SIVsmE543-3-inoculated rapid progressors to determine the contribution of viral evolution to the development of rapid disease and the effect of the absence of immune pressure upon viral evolution. PCR was used to amplify and clone the entire SIV genome from tissues collected at necropsy, and the course of viral evolution was assessed by env sequences cloned from sequential plasma samples of one rapid progressor (RP) macaque. The majority of sequence changes in RP macaques occurred in the envelope gene. Substitutions were observed in all three animals at specific conserved residues in envelope, including loss of a glycosylation site in V1/V2, a D-to-N/V substitution in a highly conserved GDPE motif, and a P-to-V/H/T substitution in the V3 loop analog. A cell-cell fusion assay revealed that representative env clones utilized CCR5 as a coreceptor, independent of CD4. The selection of specific substitutions in envelope in RP macaques suggests novel selection pressures on virus in such animals and suggests that viral variants that evolve in these animals may play a role in disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.