ArticleThe Journal of cell biology2003
deep-orange and carnation define distinct stages in late endosomal biogenesis in Drosophila melanogaster.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 90 citations in OpenAlex.
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- Loss of the HOPS complex disrupts early-to-late endosome transition, impairs endosomal recycling and induces accumulation of amphisomes.Molecular biology of the cell · 2024Article
- Deep orange gene editing triggers temperature-sensitive lethal phenotypes in Ceratitis capitata.BMC biotechnology · 2024Article
- Genomic and cytogenetic analysis of the Ceratitis capitata temperature-sensitive lethal region.G3 (Bethesda, Md.) · 2023Article
- Review
- Distinct actin-dependent nanoscale assemblies underlie the dynamic and hierarchical organization of E-cadherin.Current biology : CB · 2021Article
- Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages.Cell discovery · 2021Article
- Sec20 is Required for Autophagic and Endocytic Degradation Independent of Golgi-ER Retrograde Transport.Cells · 2019Article
- Atg1-mediated autophagy suppresses tissue degeneration inMolecular biology of the cell · 2018Article
- Neurodegeneration and locomotor dysfunction inJournal of cell science · 2018Article
- Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens.Trends in cell biology · 2018Review
- Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes.Autophagy · 2018Article
- Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis.Journal of cell science · 2017Article
- Vps33b is crucial for structural and functional hepatocyte polarity.Journal of hepatology · 2017Article
- A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila.BMC cell biology · 2016Article
- Endocytosis of Wingless via a dynamin-independent pathway is necessary for signaling inProceedings of the National Academy of Sciences of the United States of America · 2016Article
- An antibody toolkit for the study of membrane traffic in Drosophila melanogaster.Biology open · 2016Article
- Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion.Molecular biology of the cell · 2015Article
- Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Endosomal degradation is severely impaired in primary hemocytes from larvae of eye color mutants of Drosophila. Using high resolution imaging and immunofluorescence microscopy in these cells, products of eye color genes, deep-orange (dor) and carnation (car), are localized to large multivesicular Rab7-positive late endosomes containing Golgi-derived enzymes. These structures mature into small sized Dor-negative, Car-positive structures, which subsequently fuse to form tubular lysosomes. Defective endosomal degradation in mutant alleles of dor results from a failure of Golgi-derived vesicles to fuse with morphologically arrested Rab7-positive large sized endosomes, which are, however, normally acidified and mature with wild-type kinetics. This locates the site of Dor function to fusion of Golgi-derived vesicles with the large Rab7-positive endocytic compartments. In contrast, endosomal degradation is not considerably affected in car1 mutant; fusion of Golgi-derived vesicles and maturation of large sized endosomes is normal. However, removal of Dor from small sized Car-positive endosomes is slowed, and subsequent fusion with tubular lysosomes is abolished. Overexpression of Dor in car1 mutant aggravates this defect, implicating Car in the removal of Dor from endosomes. This suggests that, in addition to an independent role in fusion with tubular lysosomes, the Sec1p homologue, Car, regulates Dor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.