ArticleGenome research2003
Comparative genome organization of human, murine, and feline MHC class II region.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 101 citations in OpenAlex.
- Immunoinformatics-Guided Computational Design and In Silico Validation of Multi-Epitope Vaccine Candidates Targeting Canine and Feline Parvoviruses.Microorganisms · 2026Article
- Expansion of MHC-IIB Has Constrained the Evolution of MHC-IIA in Passerines.Genome biology and evolution · 2024Article
- Two MP2CL5 Antigen Vaccines from Naegleria fowleri Stimulate the Immune Response against Meningitis in the BALB/c Model.Infection and immunity · 2023Article
- MHC architecture in amphibians - ancestral reconstruction, gene rearrangements and duplication patterns.Genome biology and evolution · 2023Article
- Fucosylation of HLA-DRB1 regulates CD4Nature cancer · 2023Article
- Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids.Frontiers in genetics · 2022Review
- Structure and evolution of the squamate major histocompatibility complex as revealed by twoFrontiers in genetics · 2022Article
- SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses.Healthcare (Basel, Switzerland) · 2021Article
- Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).PloS one · 2021Article
- The Marine Mammal Class II Major Histocompatibility Complex Organization.Frontiers in immunology · 2019Article
- 100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB.BMC genomics · 2017Article
- Genomic structure of the horse major histocompatibility complex class II region resolved using PacBio long-read sequencing technology.Scientific reports · 2017Article
- The Reliability and Stability of an Inferred Phylogenetic Tree from Empirical Data.Molecular biology and evolution · 2017Article
- Polymorphism at expressed DQ and DR loci in five common equine MHC haplotypes.Immunogenetics · 2017Article
- A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- No Compensatory Relationship between the Innate and Adaptive Immune System in Wild-Living European Badgers.PloS one · 2016Article
- Genomic legacy of the African cheetah, Acinonyx jubatus.Genome biology · 2015Article
- Genomic organization of the crested ibis MHC provides new insight into ancestral avian MHC structure.Scientific reports · 2015Article
- Sequencing and comparative analysis of the gorilla MHC genomic sequence.Database : the journal of biological databases and curation · 2013Article
- Low MHC class II diversity in the Tasmanian devil (Sarcophilus harrisii).Immunogenetics · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
To study comparative molecular dynamics in the genesis of the major histocompatibility complex (MHC), we determined a complete nucleotide sequence spanning 758,291 bp of the domestic cat (Felis catus) extended and classical class II region. The feline class II MHC includes 44 genes (31 predicted to be expressed) which display DNA sequence homology and ordered gene synteny with human HLA and mouse H2, in extended class II and centromere proximal regions (DM to DO) of the classical class II region. However, remarkable genomic alterations including gene gain and loss plus size differentials of 250 kb are evident in comparisons of the cat class II with those of human and mouse. The cat MHC lacks the entire DQ region and retains only relict pseudogene homologs of DP genes, compensated by expansion and reorganization of seven modern DR genes. Repetitive gene families within the feline MHC comprise 35% of the feline MHC with very different density and abundance of GC levels, SINES, LINES, STRs, and retro-elements from the same repeats in human and mouse MHC. Comparison of the feline MHC with the murine and human MHC offers a detailed view of the consequences of genome organization in three mammalian lineages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.