ArticleDigestive diseases and sciences2003
Dose-response relationship and mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhea in rats.
Article in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- The preventive effects ofHeliyon · 2024Article
- Dose-Response Effect of Saccharomyces cerevisiae UFMG A-905 on the Prevention of Asthma in an Animal Model.Probiotics and antimicrobial proteins · 2024Article
- A Novel Microwave Hot Pressing Machine for Production of Fixed Oils from Different Biopolymeric Structured Tissues.Polymers · 2023Article
- Qiweibaizhu Decoction Treats Diarrheal Juvenile Rats by Modulating the Gut Microbiota, Short-Chain Fatty Acids, and the Mucus Barrier.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Diversity ofWorld journal of gastroenterology · 2019Review
- Antidiarrheal Action ofFrontiers in microbiology · 2018Article
- Castor Oil: Properties, Uses, and Optimization of Processing Parameters in Commercial Production.Lipid insights · 2016Review
- Effectiveness of Saccharomyces boulardii in a rat model of colitis.World journal of gastroenterology · 2012Article
- Use of artificial digestive systems to investigate the biopharmaceutical factors influencing the survival of probiotic yeast during gastrointestinal transit in humans.Pharmaceutical research · 2012Article
- Preventive effects of different probiotic formulations on travelers' diarrhea model in wistar rats : preventive effects of probiotics on TD.Digestive diseases and sciences · 2010Article
- Saccharomyces boulardii in childhood.European journal of pediatrics · 2009Review
- Increased intestinal delivery of viable Saccharomyces boulardii by encapsulation in microspheres.Pharmaceutical research · 2008Article
- Effects of Saccharomyces boulardii on intestinal mucosa.Digestive diseases and sciences · 2006Review
- Saccharomyces boulardii inhibits water and electrolytes changes induced by castor oil in the rat colon.Digestive diseases and sciences · 2005Article
- Studies on the time course of the effects of the probiotic yeast Saccharomyces boulardii on electrolyte transport in pig jejunum.Digestive diseases and sciences · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For biotherapeutic agents, there is a lack of information on dose-response relationships and mechanism of action. The present study was designed to address these issues for Saccharomyces boulardii using the rat model of castor oil-induced diarrhea. A single dose of Saccharomyces boulardii at 12 x 10(10) CFU/kg of viable cells given 1 hr before castor oil administration significantly reduced the onset of diarrhea. Repeated ingestion of the yeast, twice daily between 1.2 and 12 x 10(10) CFU/kg for 5 days before castor oil, showed a dose-response relationship. The percentage of rats with diarrhea decreased and a stronger protection was afforded by the repeated treatment. The mechanism of action of Saccharomyces boulardii in this model was investigated with two classes of antagonists, naloxone and L-arginine. The effect of Saccharomyces boulardii was not inhibited by naloxone but was significantly reduced by L-arginine. This last result suggests a novel mechanism of action for Saccharomyces boulardii involving a possible inhibition of nitric oxide production by the yeast.
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