ArticleDevelopment genes and evolution2003
A genomewide survey of developmentally relevant genes in Ciona intestinalis. IX. Genes for muscle structural proteins.
Article in Development genes and evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 58 citations in OpenAlex.
- A gene regulatory network for specification and morphogenesis of a Mauthner Cell homolog in non-vertebrate chordates.Developmental biology · 2025Article
- Ascidian embryonic cells with properties of neural-crest cells and neuromesodermal progenitors of vertebrates.Nature ecology & evolution · 2024Article
- Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart.Nature communications · 2023Article
- Genome-Wide Identification, Comparison, and Expression Analysis of Transcription Factors in AscidianInternational journal of molecular sciences · 2021Article
- Apoptosis is a generator of Wnt-dependent regeneration and homeostatic cell renewal in the ascidian Ciona.Biology open · 2021Article
- The origin of the expressed retrotransposed gene ACTBL2 and its influence on human melanoma cells' motility and focal adhesion formation.Scientific reports · 2021Article
- Expression of smooth muscle-like effectors and core cardiomyocyte regulators in the contractile papillae ofEvoDevo · 2020Article
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- Deuterostome Genomics: Lineage-Specific Protein Expansions That Enabled Chordate Muscle Evolution.Molecular biology and evolution · 2018Article
- Article
- Functional studies of the Ciona intestinalis myogenic regulatory factor reveal conserved features of chordate myogenesis.Developmental biology · 2013Article
- Muscle differentiation in a colonial ascidian: organisation, gene expression and evolutionary considerations.BMC developmental biology · 2009Article
- Comparative genomic analysis of the arthropod muscle myosin heavy chain genes allows ancestral gene reconstruction and reveals a new type of 'partially' processed pseudogene.BMC molecular biology · 2008Article
- Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development.Genes & development · 2006Article
- Expression of a muscle determinant gene, macho-1, in the anural ascidian Molgula tectiformis.Development genes and evolution · 2006Article
- Noncoding regulatory sequences of Ciona exhibit strong correspondence between evolutionary constraint and functional importance.Genome research · 2004Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ascidians are simple chordates that are related to, and may resemble, vertebrate ancestors. Comparison of ascidian and vertebrate genomes is expected to provide insight into the molecular genetic basis of chordate/vertebrate evolution. We annotated muscle structural (contractile protein) genes in the completely determined genome sequence of the ascidian Ciona intestinalis, and examined gene expression patterns through extensive EST analysis. Ascidian muscle protein isoform families are generally of similar, or lesser, complexity in comparison with the corresponding vertebrate isoform families, and are based on gene duplication histories and alternative splicing mechanisms that are largely or entirely distinct from those responsible for generating the vertebrate isoforms. Although each of the three ascidian muscle types - larval tail muscle, adult body-wall muscle and heart - expresses a distinct profile of contractile protein isoforms, none of these isoforms are strictly orthologous to the smooth-muscle-specific, fast or slow skeletal muscle-specific, or heart-specific isoforms of vertebrates. Many isoform families showed larval-versus-adult differential expression and in several cases numerous very similar genes were expressed specifically in larval muscle. This may reflect different functional requirements of the locomotor larval muscle as opposed to the non-locomotor muscles of the sessile adult, and/or the biosynthetic demands of extremely rapid larval development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.