ArticleMolecular psychiatry2003
Linkage of schizophrenia with chromosome 1q loci in Taiwanese families.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 130 citations in OpenAlex.
- A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia.Molecular psychiatry · 2005Trial
- A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42.Molecular psychiatry · 2004Trial
- Replication of 1q42 linkage in Finnish schizophrenia pedigrees.Molecular psychiatry · 2004Trial
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- Evidence for an Association Between a pH-Dependent Potassium Channel, TWIK-1, and the Accuracy of Smooth Pursuit Eye Movements.Investigative ophthalmology & visual science · 2024Article
- Schizophrenia in the genetic era: a review from development history, clinical features and genomic research approaches to insights of susceptibility genes.Metabolic brain disease · 2024Review
- Mutations in DISC1 alter IPNeuronal signaling · 2021Review
- The Roles of Peroxiredoxin 6 in Brain Diseases.Molecular neurobiology · 2021Review
- Genetic EffectsNeuropsychiatric disease and treatment · 2020Article
- Altered White Matter and Layer VIb Neurons in HeterozygousFrontiers in neuroanatomy · 2020Article
- Genetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia.Journal of human genetics · 2019Article
- A Gene-Based Analysis of Acoustic Startle Latency.Frontiers in psychiatry · 2017Article
- Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness.Molecular neuropsychiatry · 2015Article
- Nitric oxide synthase 1 adaptor protein, a protein implicated in schizophrenia, controls radial migration of cortical neurons.Biological psychiatry · 2015Article
- The DAO gene is associated with schizophrenia and interacts with other genes in the Taiwan Han Chinese population.PloS one · 2013Article
- Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients.Translational psychiatry · 2012Article
- Systems biology, bioinformatics, and biomarkers in neuropsychiatry.Frontiers in neuroscience · 2012Article
- Article
- Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.Neuroscience and biobehavioral reviews · 2011Review
- Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls.BMC medical genetics · 2010Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A positive linkage of schizophrenia with chromosome 1q loci has been reported in Caucasian patients. This study was designed to evaluate the linkage of schizophrenia with markers of the 1q22-44 region in 52 Taiwanese families with at least two affected siblings. In the region 1q22-31 (17.8 cM), marker D1S1679 had a maximal proportion (0.57, P=0.03) of shared identity by descent (IBD) under a narrow phenotype (DSM-IV schizophrenia only). In the region 1q42-44 (26.8 cM), the marker D1S251, located near the breakpoint of a balanced translocation t (1;11) (q42.1;q14.3) segregated with schizophrenia, and also near the neurodevelopment-related 'Disrupted in Schizophrenia 1' gene, had a maximum NPL score of 1.73 (P=0.03) under the narrow phenotype model and 2.18 (P=0.01) under the broad phenotype model comprised of schizophrenia, schizoaffective disorder, and other nonaffective psychotic disorders as defined by DSM-IV criteria. The marker D1S2836 also had a maximal proportion (0.57, P=0.05) of shared IBD under the broad model. These findings may provide guidance for positional cloning studies on candidate genes in the 1q22-31 and 1q41-44 regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.