ArticleMolecular psychiatry2003
Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 156 citations in OpenAlex.
- Endogenous opioid receptors and the feast or famine of maladaptive feeding.Nature communications · 2025Review
- HTR1D regulates the PI3K/Akt signaling pathway to impact hepatocellular carcinoma development and resistance to sorafenib.BMC cancer · 2025Article
- Association ofJournal of clinical medicine · 2024Article
- Role of Endogenous Opioids in the Pathophysiology of Obesity and Eating Disorders.Advances in neurobiology · 2024Review
- Genetic contributions to the etiology of anorexia nervosa: New perspectives in molecular diagnosis and treatment.Molecular genetics & genomic medicine · 2020Review
- Sex Differences in Adolescent Anorexia and Bulimia Nervosa: Beyond the Signs and Symptoms.Current psychiatry reports · 2019Review
- Genetic risk factors for eating disorders: an update and insights into pathophysiology.Therapeutic advances in psychopharmacology · 2019Review
- 5-HT3 Receptors: A Potential Therapeutic Target for Epilepsy.Current neuropharmacology · 2018Review
- Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa.Prostaglandins & other lipid mediators · 2017Article
- The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (Disease models & mechanisms · 2017Article
- Article
- Machine learning derived risk prediction of anorexia nervosa.BMC medical genomics · 2016Article
- New Insights in Anorexia Nervosa.Frontiers in neuroscience · 2016Review
- Genetic neuropathology of obsessive psychiatric syndromes.Translational psychiatry · 2014Article
- Genetic variants associated with disordered eating.The International journal of eating disorders · 2013Article
- Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36.Biological psychiatry · 2012Article
- Antipsychotic agents in the treatment of anorexia nervosa: neuropsychopharmacologic rationale and evidence from controlled trials.Current psychiatry reports · 2012Review
- A debate on current eating disorder diagnoses in light of neurobiological findings: is it time for a spectrum model?BMC psychiatry · 2012Article
- Olanzapine, but not fluoxetine, treatment increases survival in activity-based anorexia in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Genetics and Epigenetics of Eating Disorders.Psychiatric annals · 2011Article
Corrections and comments
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Authors and funding
19 authors at 14 institutions in 4 countries.
Funding
Abstract
Serotonergic and opioidergic neurotransmitter system alterations have been observed in people with eating disorders; the genes for the serotonin 1D receptor (HTR1D) and the opioid delta receptor (OPRD1) are found on chr1p36.3-34.3, a region identified by our group in a linkage analysis of anorexia nervosa (AN). These candidate genes were evaluated for sequence variation and for linkage and association of this sequence variation to AN in family and case : control data sets. Resequencing of the HTR1D locus and a portion of the OPRD1 locus identified novel SNPs and confirmed existing SNPs. Genotype assay development and genotyping of nine SNPs (four at HTR1D and five at OPRD1) was performed on 191 unrelated individuals fulfilling DSM-IV criteria (w/o amenorrhea criterion) for AN, 442 relatives of AN probands and 98 psychiatrically screened controls. Linkage analysis of these candidate gene SNPs with 33 microsatellite markers in families including relative pairs concordantly affected with restricting AN (N=37) substantially increased the evidence for linkage of this region to restricting AN to an NPL score of 3.91. Statistically significant genotypic, allelic, and haplotypic association to AN in the case : control design was observed at HTR1D and OPRD1 with effect sizes for individual SNPs of 2.63 (95% CI=1.21-5.75) for HTR1D and 1.61 (95% CI=1.11-2.44) for OPRD1. Using genotype data on parents and AN probands, three SNPs at HTR1D were found to exhibit significant transmission disequilibrium (P&<0.05). The combined statistical genetic evidence suggests that HTR1D and OPRD1 or linked genes may be involved in the etiology of AN.
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