ArticleProceedings of the National Academy of Sciences of the United States of America2003
Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
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142 citing papers in PubMed, 412 citations in OpenAlex.
- The OsUVR8-OsNAC3-OsERF117 signaling module mediates metabolic acclimation and climate adaptation in rice.Science advances · 2026Article
- Mitochondrial gene orf224 triggers retrograde signaling and reprogramming of anther cell fate in Brassica napus Polima CMS.The New phytologist · 2026Article
- Identification and expression of the Glycyrrhiza uralensis GABA shunt gene family under drought and salt stress with exogenous GABA.Scientific reports · 2026Article
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- Not just a cycle: mitochondrial CsgabD is involved in GABA metabolism during citrus defense against biotic stress.Plant molecular biology · 2026Article
- Multi-omic profiles of Sorghum genotypes with contrasting heat tolerance connect pathways related to thermotolerance.Journal of experimental botany · 2025Article
- Aldehyde dehydrogenase activity is induced by oxygen exposure in the anaerobic archaeon Methanosarcina acetivorans.World journal of microbiology & biotechnology · 2025Article
- Quantitative proteomic analysis deciphers mechanisms of sheath blight resistance in novel rice landrace against Rhizoctonia solani.Scientific reports · 2025Article
- Gamma-Aminobutyric Acid: A Novel Biomolecule to Improve Plant Resistance and Fruit Quality.Plants (Basel, Switzerland) · 2025Review
- Transcriptomic Insights into GABA Accumulation in Tomato via CRISPR/Cas9-Based Editing ofGenes · 2025Article
- Gamma-aminobutyric acid (GABA) releases seed dormancy by orchestrating abscisic acid and gibberellin metabolism and signaling.BMC plant biology · 2025Article
- Genome-Wide Identification and Expression Analysis Unveil the Involvement of the Succinic Semialdehyde Dehydrogenase (International journal of molecular sciences · 2025Article
- The Role of Glutamate Metabolism and the GABA Shunt in Bypassing the Tricarboxylic Acid Cycle in the Light.International journal of molecular sciences · 2024Article
- GABA transport: beyond stress? A closer look at AtGAT2.Journal of experimental botany · 2024Article
- Relationship between the GABA Pathway and Signaling of Other Regulatory Molecules.International journal of molecular sciences · 2024Review
- Flagellin Induced GABA-shunt improves Drought stress tolerance in Brassica napus L.BMC plant biology · 2024Article
- Gamma-aminobutyric acid interactions with phytohormones and its role in modulating abiotic and biotic stress in plants.Stress biology · 2024Review
- Article
- Integrative omics analysis elucidates the genetic basis underlying seed weight and oil content in soybean.The Plant cell · 2024Article
- Truncation of the calmodulin binding domain in rice glutamate decarboxylase 4 (Molecular breeding : new strategies in plant improvement · 2024Article
82 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gamma-aminobutyrate (GABA) shunt is a metabolic pathway that bypasses two steps of the tricarboxylic acid cycle, and it is present in both prokaryotes and eukaryotes. In plants the pathway is composed of the calcium/calmodulin-regulated cytosolic enzyme glutamate decarboxylase and the mitochondrial enzymes GABA transaminase and succinic-semialdehyde dehydrogenase (SSADH). The activity of the GABA shunt in plants is rapidly enhanced in response to various biotic and abiotic stresses. However the physiological role of this pathway remains obscure. To elucidate its role in plants, we analyzed Arabidopsis T-DNA knockout mutants of SSADH, the ultimate enzyme of the pathway. Four alleles of the ssadh mutation were isolated, and these exhibited a similar phenotype. When exposed to white light (100 micromol of photons per m2 per s), they appear dwarfed with necrotic lesions. Detailed spectrum analysis revealed that UV-B has the most adverse effect on the mutant phenotype, whereas photosynthetic active range light has a very little effect. The ssadh mutants are also sensitive to heat, as they develop necrosis when submitted to such stress. Moreover, both UV and heat cause a rapid increase in the levels of hydrogen peroxide in the ssadh mutants, which is associated with enhanced cell death. Surprisingly, our study also shows that trichomes are hypersensitive to stresses in ssadh mutants. Our work establishes a role for the GABA shunt in preventing the accumulation of reactive oxygen intermediates and cell death, which appears to be essential for plant defense against environmental stress.
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