ArticleProceedings of the National Academy of Sciences of the United States of America2003
T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease.Cardiovascular drugs and therapy · 2013Trial
- Functional Role of Single-Nucleotide Polymorphisms on IFNG and IFNGR1 in Humans with Cardiovascular Disease.International journal of molecular sciences · 2025Article
- Blood eosinophil count is associated with early atherosclerotic artery changes in asthma.BMC pulmonary medicine · 2024Article
- One-year longitudinal changes of peripheral CD4+ T-lymphocyte counts, gut microbiome, and plaque vulnerability after an acute coronary syndrome.International journal of cardiology. Heart & vasculature · 2024Article
- Clonally expanded memory CD8Nature aging · 2023Article
- Piceatannol induces regulatory T cells and modulates the inflammatory response and adipogenesis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Article
- Persistent Asthma Is Associated With Carotid Plaque in MESA.Journal of the American Heart Association · 2022Article
- Understanding Immune Responses to Viruses-Do Underlying Th1/Th2 Cell Biases Predict Outcome?Viruses · 2022Review
- Long-Term Consequences of Placental Vascular Pathology on the Maternal and Offspring Cardiovascular Systems.Biomolecules · 2021Review
- Review
- Inflammatory Chemokines in Atherosclerosis.Cells · 2021Review
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- Intrinsic factor recognition promotes T helper 17/T helper 1 autoimmune gastric inflammation in patients with pernicious anemia.Oncotarget · 2019Article
- Readapting the adaptive immune response - therapeutic strategies for atherosclerosis.British journal of pharmacology · 2017Review
- Batf3-dependent CD8αEBioMedicine · 2017Article
- Persistent and selective upregulation of renin-angiotensin system in circulating T lymphocytes in unstable angina.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2017Article
- Article
- Functional and homeostatic defects of regulatory T cells in patients with coronary artery disease.Journal of internal medicine · 2016Article
- Role of Helicobacter pylori infection in pathogenesis of atherosclerosis.World journal of cardiology · 2015Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerotic lesions are infiltrated by macrophages and T lymphocytes, potentially reactive to pathogens. We studied in vivo activated T lymphocytes that infiltrate atherosclerotic plaques of Helicobacter pylori-infected patients with or without anti-Chlamydia pneumoniae antibodies. In all atherosclerotic lesions, T helper type 1 (Th1) cells were predominant. C. pneumoniae-specific T cells were detected only in the plaques of anti-C. pneumoniae seropositive patients, whereas H. pylori-specific T cells were found in the gastric mucosa but not in the plaques of the same patients. Plaque-derived Th1 cells expressed cytotoxicity, proapoptotic activity, and help for monocyte tissue factor production. Although multifactorial, atherosclerosis can be regarded as a Th1-driven immunopathological condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.