ArticleGut2003
Relations between amount and type of alcohol and colon and rectal cancer in a Danish population based cohort study.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Meta-analyses of colorectal cancer risk factors.Cancer causes & control : CCC · 2013Pooled it
- Inverse relationship between moderate alcohol intake and rectal cancer: analysis of the North Carolina Colon Cancer Study.Diseases of the colon and rectum · 2011Trial
- Medical treatment cost for Chinese inpatients with colorectal cancer by sites.Frontiers in public health · 2025Observational
- Harnessing Artificial Intelligence for the Detection and Management of Colorectal Cancer Treatment.Cancer prevention research (Philadelphia, Pa.) · 2024Review
- Review
- The association of smoking and alcohol in colorectal cancer in black patients - Case-control study.Journal of public health in Africa · 2024Article
- Review
- Geographic Variation and Risk Factor Association of Early Versus Late Onset Colorectal Cancer.Cancers · 2023Article
- Association between wine consumption and cancer: a systematic review and meta-analysis.Frontiers in nutrition · 2023Review
- Effects of Alcohol Consumption on Various Systems of the Human Body: A Systematic Review.Cureus · 2022Review
- Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database.British journal of cancer · 2022Article
- Review
- Risk Factors for Colorectal Adenocarcinoma in an Indigenous Population in East Africa.Cancer management and research · 2022Article
- Alcohol Consumption, HDL-Cholesterol and Incidence of Colon and Rectal Cancer: A Prospective Cohort Study Including 250,010 Participants.Alcohol and alcoholism (Oxford, Oxfordshire) · 2021Article
- Diet and colorectal cancer in UK Biobank: a prospective study.International journal of epidemiology · 2020Article
- Risk of colorectal cancer in patients with alcoholism: A nationwide, population-based nested case-control study.PloS one · 2020Article
- The presence of bacteria varies between colorectal adenocarcinomas, precursor lesions and non-malignant tissue.BMC cancer · 2019Article
- Article
- Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps.International journal of colorectal disease · 2017Article
- Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population.World journal of gastroenterology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere may be a weak association between total alcohol intake and colorectal cancer but the effect of different types of alcohol and effect on colon subsites have not been investigated satisfactorily.
aimsTo investigate the relationship between amount and type of alcohol and the risk of colon and rectal cancer. SUBJECTS: A population based cohort study with baseline assessment of weekly intake of beer, wine, and spirits, smoking habits, body mass index, educational level, and leisure time physical activity in Copenhagen, Denmark. The study included a random sample of 15 491 men and 13 641 women, aged 23-95 years. Incident cases of colorectal cancer were identified in the nationwide Danish Cancer Register.
resultsDuring a mean follow up of 14.7 years, we observed 411 colon cancers and 202 rectal cancers. We observed a dose-response relationship between alcohol and rectal cancer. Drinkers of more than 41 drinks a week had a relative risk of rectal cancer of 2.2 (95% confidence limits 1.0-4.6) compared with non-drinkers. Drinkers of more than 14 drinks of beer and spirits a week, but not wine, had a risk of 3.5 (1.8-6.9) of rectal cancer compared with non-drinkers, while those who drank the same amount of alcohol but including more than 30% of wine had a risk of 1.8 (1.0-3.2) of rectal cancer. No relation between alcohol and colon cancer was found when investigating the effects of total alcohol, beer, wine, and spirits, and percentage of wine of total alcohol intake.
conclusionAlcohol intake is associated with a significantly increased risk of rectal cancer but the risk seems to be reduced when wine is included in the alcohol intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.