ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2003
The discovery of long-term potentiation.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
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- A three-dimensional model of neural activity and phenomenal-behavioral patterns.Molecular psychiatry · 2024Review
- Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity.Frontiers in aging neuroscience · 2024Review
- Synaptic sensitization in the anterior cingulate cortex sustains the consciousness of pain via synchronized oscillating electromagnetic waves.Frontiers in human neuroscience · 2024Article
- Advances in the Electrophysiological Recordings of Long-Term Potentiation.International journal of molecular sciences · 2023Review
- Toward the unknown: consciousness and pain.Neuroscience of consciousness · 2023Article
- Sensory tetanisation to induce long-term-potentiation-like plasticity: A review and reassessment of the approach.The European journal of neuroscience · 2022Review
- Optogenetics: implications for Alzheimer's disease research and therapy.Molecular brain · 2022Review
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- Non-invasive brain stimulation and pain neuroscience education in the cognitive-affective treatment of chronic low back pain: Evidence and future directions.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- The Structural Basis of Long-Term Potentiation in Hippocampal Synapses, Revealed by Electron Microscopy Imaging of Lanthanum-Induced Synaptic Vesicle Recycling.Frontiers in cellular neuroscience · 2022Article
- Epileptic seizures and link to memory processes.AIMS neuroscience · 2022Article
- GABACurrent topics in behavioral neurosciences · 2022Review
- Serine/Threonine Phosphatases in LTP: Two B or Not to Be the Protein Synthesis Blocker-Induced Impairment of Early Phase.International journal of molecular sciences · 2021Article
- Neurobiology of reward-related learning.Neuroscience and biobehavioral reviews · 2021Review
- Feasibility of cerium-doped LSO particles as a scintillator for x-ray induced optogenetics.Journal of neural engineering · 2021Article
- Plasticity in the Hippocampus, Neurogenesis and Drugs of Abuse.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
1 author.
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Abstract
This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen's laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule cells in the hippocampus of anaesthetized rabbits, I observed that brief trains of stimuli resulted in increased efficiency of transmission at the perforant path-granule cell synapses that could last for hours. In 1968, Tim Bliss came to Per Andersen's laboratory to learn about the hippocampus and field potential recording for studies of possible memory mechanisms. The two of us then followed up my preliminary results from 1966 and did the experiments that resulted in a paper that is now properly considered to be the basic reference for the discovery of LTP.
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