ArticlePflugers Archiv : European journal of physiology2003
Human skeletal muscle mitochondrial metabolism in youth and senescence: no signs of functional changes in ATP formation and mitochondrial oxidative capacity.
Article in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Estimated standard values of aerobic capacity according to sex and age in a Japanese population: A scoping review.PloS one · 2023Pooled it
- Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- Review
- Oxygen delivery and consumption in aging skeletal muscle: Insights from an electric analogy model of POPhysiological reports · 2026Article
- Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR).The journal of nutrition, health & aging · 2025Review
- Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA).Journal of sport and health science · 2024Article
- Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing.Sports medicine (Auckland, N.Z.) · 2024Review
- Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing.The Journal of physiology · 2021Article
- Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia.Journal of translational medicine · 2021Review
- Mitochondrial lactate metabolism: history and implications for exercise and disease.The Journal of physiology · 2021Review
- Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults.Journal of cachexia, sarcopenia and muscle · 2018Article
- Lactate metabolism: historical context, prior misinterpretations, and current understanding.European journal of applied physiology · 2018Review
- Mitochondria as a Target for Mitigating Sarcopenia.Frontiers in physiology · 2018Review
- Structure and function of human muscle fibres and muscle proteome in physically active older men.The Journal of physiology · 2017Article
- Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Exercise capacity, physical activity, and morbidity.Heart failure reviews · 2017Review
- Mitochondrial Bioenergetics in the Metabolic Myopathy Accompanying Peripheral Artery Disease.Frontiers in physiology · 2017Review
- A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function.The Journal of physiology · 2015Article
- Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle.American journal of physiology. Endocrinology and metabolism · 2015Article
- Skeletal muscle mitochondrial energetic efficiency and aging.International journal of molecular sciences · 2015Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitochondrial theory of ageing was tested. Isolated mitochondria from the quadriceps muscle from normal, healthy, young (age 20+ years, n=12) and elderly (70+ years, n=11) humans were studied in respiratory experiments and the data expressed as activities of the muscle. In each group, the subjects exhibited a variation of physical activity but, on average, the groups were representative for their age with maximum O(2) consumption rate of 50+/-9 and 34+/-13 ml min(-1) kg(-1) (mean+/-SD), respectively. Thirteen different activities were assayed. alpha-Glycerophosphate oxidation was lower in the 70+ group (38%, P~0.001), as was the respiratory capacity for fatty acids (19%, P~0.03). The remaining eleven activities, including those of the central bioenergetic reactions, were not lower in the 70+ group. Pyruvate and alpha-ketoglutarate dehydrogenase activities (i.e. the tricarboxylic acid cycle turnover) and the respiratory chain activity could all account for ~14 mmol O(2) min(-1) kg(-1) muscle (37 degrees C). The capacity for aerobic ATP synthesis was ~35 mmol ATP min(-1) kg(-1). The mitochondrial capacities were far in excess of whole-body performance. They were related to physical activity, but not to age. The mitochondrial theory of ageing, which attributes the age-related decline of muscle performance to decreased mitochondrial function, is incompatible with these results.
Indexed as
Identifiers
12739165What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.