Evidence map›Paper›PMID 12739143›Full record

ArticleDevelopment genes and evolution2003

Cloning and expression patterns of dystroglycan during the early development of Xenopus laevis.

Nicole Moreau, Dominique Alfandari, Alban Gaultier, Hélène Cousin, Thierry Darribère

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Development genes and evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Nicole MoreauUniversité Pierre et Marie Curie, Laboratoire de Biologie du Développement, UMR CNRS 7622, 9 quai Saint Bernard, 75005 Paris, France.
Dominique Alfandari
Alban Gaultier
Hélène Cousin
Thierry Darribère
Sorbonne Université · FRUniversity of Virginia · USCentre National de la Recherche Scientifique · FR

Funding

ADAM FUNCTION IN NEURAL CREST CELLSR01DE014365 · NIDCR · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI DESIMONE, DOUGLAS W. · 2002 to 2006
$1.8M
NIDCR NIH HHS DE14365
6 · The paper itself

Abstract

Dystroglycan is a cell surface receptor involved in the pathogenesis of muscular dystrophy, and plays a critical role in the assembly and homeostasis of basement membranes. Since data about the amphibian homologue are limited, we have cloned the full-length dystroglycan cDNAs from the frog Xenopus laevis. Using in situ hybridization, we show that mRNA expression is dynamic, particularly in the notochord at the end of gastrulation and during neurulation, suggesting that the protein might play unexplored roles in the specification and/or formation of this tissue. Subsequently, the transcripts are detected in the otic vesicle, the developing brain, and in mesenchymal cells of the visceral arches, as well as in pharyngeal endoderm, the pronephros, pronephric ducts, proctodaeum and the somites.

Indexed as

Amino Acid SequenceAnimalsCloning, MolecularCytoskeletal ProteinsDNA, ComplementaryDystroglycansGene Expression Regulation, DevelopmentalIn Situ HybridizationMembrane GlycoproteinsMolecular Sequence DataSequence AlignmentSequence Analysis, ProteinXenopus laevisCytoskeletal ProteinsDNA, ComplementaryDystroglycansMembrane Glycoproteins

Identifiers

PMID12739143
OpenAlexW2132743641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.