ArticleEuropean biophysics journal : EBJ2003
Analysis of actin dynamics at the leading edge of crawling cells: implications for the shape of keratocyte lamellipodia.
Article in European biophysics journal : EBJ, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 110 citations in OpenAlex.
- A phase field model with stochastic input simulates cellular gradient sensing, morphodynamics, and fidelity of haptotaxis.PLoS computational biology · 2026Article
- A phase field model with stochastic input simulates cellular gradient sensing, morphodynamics, and fidelity of haptotaxis.bioRxiv : the preprint server for biology · 2026Article
- Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism.Molecular biology of the cell · 2023Article
- Crawling, waving, inch worming, dilating, and pivoting mechanics of migrating cells: Lessons from Ken Jacobson.Biophysical journal · 2023Review
- Leading edge maintenance in migrating cells is an emergent property of branched actin network growth.eLife · 2022Article
- Actin-Membrane Release Initiates Cell Protrusions.Developmental cell · 2020Article
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Correlated random walks inside a cell: actin branching and microtubule dynamics.Journal of mathematical biology · 2019Article
- Sharp interface model for elastic motile cells.The European physical journal. E, Soft matter · 2019Article
- Existence of and decay to equilibrium of the filament end density along the leading edge of the lamellipodium.Journal of mathematical biology · 2017Article
- Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase.The Journal of cell biology · 2015Article
- Multiscale modeling of cell shape from the actin cytoskeleton.Progress in molecular biology and translational science · 2014Review
- The role of the actin cortex in maintaining cell shape.Communicative & integrative biology · 2013Article
- Mathematical modeling of eukaryotic cell migration: insights beyond experiments.Annual review of cell and developmental biology · 2013Review
- Signaling regulated endocytosis and exocytosis lead to mating pheromone concentration dependent morphologies in yeast.FEBS letters · 2012Article
- Excitable actin dynamics in lamellipodial protrusion and retraction.Biophysical journal · 2012Article
- A comparison of computational models for eukaryotic cell shape and motility.PLoS computational biology · 2012Review
- Electrotaxis of oral squamous cell carcinoma cells in a multiple-electric-field chip with uniform flow field.Biomicrofluidics · 2012Article
- How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility.PLoS computational biology · 2012Article
- Actin disassembly clock determines shape and speed of lamellipodial fragments.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leading edge protrusion is one of the critical events in the cell motility cycle and it is believed to be driven by the assembly of the actin network. The concept of dendritic nucleation of actin filaments provides a basis for understanding the organization and dynamics of the actin network at the molecular level. At a larger scale, the dynamic geometry of the cell edge has been described in terms of the graded radial extension model, but this level of description has not yet been linked to the molecular dynamics. Here, we measure the graded distribution of actin filament density along the leading edge of fish epidermal keratocytes. We develop a mathematical model relating dendritic nucleation to the long-range actin distribution and the shape of the leading edge. In this model, a steady-state graded actin distribution evolves as a result of branching, growth and capping of actin filaments in a finite area of the leading edge. We model the shape of the leading edge as a product of the extension of the actin network, which depends on actin filament density. The feedback between the actin density and edge shape in the model results in a cell shape and an actin distribution similar to those experimentally observed. Thus, we explain the stability of the keratocyte shape in terms of the self-organization of the branching actin network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.