ArticleClinical and diagnostic laboratory immunology2003
Respiratory disease in kennelled dogs: serological responses to Bordetella bronchiseptica lipopolysaccharide do not correlate with bacterial isolation or clinical respiratory symptoms.
Article in Clinical and diagnostic laboratory immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Clinical features, risk factors, and outcomes of Bordetella bronchiseptica respiratory infections in dogs diagnosed at a tertiary care institution.Journal of veterinary internal medicine · 2026Article
- Investigation of the Correlation Between ELISA and Serum Amyloid A in the Diagnosis of Bordetella bronchiseptica in Dogs.Veterinary medicine and science · 2025Article
- Review
- Aetiology of Canine Infectious Respiratory Disease Complex and Prevalence of its Pathogens in Europe.Journal of comparative pathology · 2020Review
- Canine Infectious Respiratory Disease.The Veterinary clinics of North America. Small animal practice · 2020Review
- Respiratory Dysbiosis in Canine Bacterial Pneumonia: Standard Culture vs. Microbiome Sequencing.Frontiers in veterinary science · 2019Article
- A Unique Capsule Locus in the Newly Designated Actinobacillus pleuropneumoniae Serovar 16 and Development of a Diagnostic PCR Assay.Journal of clinical microbiology · 2017Article
- Quantitative PCR and Cytology of Bronchoalveolar Lavage Fluid in Dogs with Bordetella bronchiseptica Infection.Journal of veterinary internal medicine · 2016Article
- Detection of non-primate hepaciviruses in UK dogs.Virology · 2015Article
- The challenges in developing effective canine infectious respiratory disease vaccines.The Journal of pharmacy and pharmacology · 2015Review
- Antimicrobial Susceptibility of Bordetella bronchiseptica Isolates from Swine and Companion Animals and Detection of Resistance Genes.PloS one · 2015Article
- Detection of respiratory viruses and Bordetella bronchiseptica in dogs with acute respiratory tract infections.Veterinary journal (London, England : 1997) · 2014Article
- Molecular identification of Mycoplasma cynos from laboratory beagle dogs with respiratory disease.Laboratory animal research · 2012Article
- Seroepidemiology of respiratory (group 2) canine coronavirus, canine parainfluenza virus, and Bordetella bronchiseptica infections in urban dogs in a humane shelter and in rural dogs in small communities.The Canadian veterinary journal = La revue veterinaire canadienne · 2011Article
- Expression of beta-defensins in the canine respiratory tract and antimicrobial activity against Bordetella bronchiseptica.Veterinary immunology and immunopathology · 2010Article
- Strain typing of Mycoplasma cynos isolates from dogs with respiratory disease.Veterinary microbiology · 2009Article
- Canine respiratory coronavirus: an emerging pathogen in the canine infectious respiratory disease complex.The Veterinary clinics of North America. Small animal practice · 2008Review
- Serological evidence of Mycoplasma cynos infection in canine infectious respiratory disease.Veterinary microbiology · 2007Article
- Serological prevalence of canine respiratory coronavirus.Veterinary microbiology · 2006Article
- Longitudinal study of viruses associated with canine infectious respiratory disease.Journal of clinical microbiology · 2004Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of Bordetella bronchiseptica in a natural outbreak of canine infectious respiratory disease was investigated both by culture and serological analysis. B. bronchiseptica was found in the lungs of a large proportion of clinically healthy dogs and in a greater proportion of dogs with respiratory disease. Using a lipopolysaccharide (LPS) antigen-based enzyme-linked immunosorbent assay, we analyzed the serological responses of a large number of dogs. Dogs with high antibody levels showed no protection from disease, and there was no correlation between the development of disease and rising antibody titer. Similarly, there was no difference in antibody levels in dogs with and without B. bronchiseptica in the lungs. Antibodies to LPS have no predictive value in determining which animals will contract respiratory disease, how severe the disease will be, or which dogs will have B. bronchiseptica colonizing the lungs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.