ArticleAmerican journal of physiology. Heart and circulatory physiology2003
Transient transcapillary exchange of water driven by osmotic forces in the heart.
Article in American journal of physiology. Heart and circulatory physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Mass Transfer in Cryopreservation at Multiple Scales: Cells, Tissues, and Organs.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Real-time estimations of blood glucose concentrations from sweat measurements using the local density random walk model.Medical & biological engineering & computing · 2025Article
- Non-Invasive Blood Cortisol Estimation from Sweat Analysis by Kinetic Modeling of Cortisol Transport Dynamics.Sensors (Basel, Switzerland) · 2025Article
- A novel kinetic model estimating the urea concentration in plasma during non-invasive sweat-based monitoring in hemodialysis.Frontiers in physiology · 2025Article
- Article
- Osmotic response during kidney perfusion with cryoprotectant in isotonic or hypotonic vehicle solution.PeerJ · 2023Article
- Transcapillary transport of water, small solutes and proteins during hemodialysis.Scientific reports · 2020Article
- Regulation of the glucose supply from capillary to tissue examined by developing a capillary model.The journal of physiological sciences : JPS · 2018Article
- Model of fluid and solute shifts during hemodialysis with active transport of sodium and potassium.PloS one · 2018Article
- Modeling Fatty Acid Transfer from Artery to Cardiomyocyte.PLoS computational biology · 2015Article
- Aquaporin-1 Deficiency Protects Against Myocardial Infarction by Reducing Both Edema and Apoptosis in Mice.Scientific reports · 2015Article
- Genetic deletion of aquaporin-1 results in microcardia and low blood pressure in mouse with intact nitric oxide-dependent relaxation, but enhanced prostanoids-dependent relaxation.Pflugers Archiv : European journal of physiology · 2014Article
- Modeling serotonin uptake in the lung shows endothelial transporters dominate over cleft permeation.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Downregulation of aquaporin-1 in alveolar microvessels in lungs adapted to chronic heart failure.Lung · 2011Article
- Microcirculation and the physiome projects.Microcirculation (New York, N.Y. : 1994) · 2008Review
- GENTEX, a general multiscale model for in vivo tissue exchanges and intraorgan metabolism.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2006Article
- A practical extension of hydrodynamic theory of porous transport for hydrophilic solutes.Microcirculation (New York, N.Y. : 1994) · 2006Article
- Multiscale modeling of cardiac cellular energetics.Annals of the New York Academy of Sciences · 2005Review
- Aquaporins in development -- a review.Reproductive biology and endocrinology : RB&E · 2005Review
- An integrative model of coupled water and solute exchange in the heart.American journal of physiology. Heart and circulatory physiology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Osmotic transient responses in organ weight after changes in perfusate osmolarity have implied steric hindrance to small-molecule transcapillary exchange, but tracer methods do not. We obtained osmotic weight transient data in isolated, Ringer-perfused rabbit hearts with NaCl, urea, glucose, sucrose, raffinose, inulin, and albumin and analyzed the data with a new anatomically and physicochemically based model accounting for 1) transendothelial water flux, 2) two sizes of porous passages across the capillary wall, 3) axial intracapillary concentration gradients, and 4) water fluxes between myocytes and interstitium. During steady-state conditions approximately 28% of the transcapillary water flux going to form lymph was through the endothelial cell membranes [capillary hydraulic conductivity (Lp) = 1.8 +/- 0.6 x 10-8 cm. s-1. mmHg-1], presumably mainly through aquaporin channels. The interendothelial clefts (with Lp = 4.4 +/- 1.3 x 10-8 cm. s-1. mmHg-1) account for 67% of the water flux; clefts are so wide (equivalent pore radius was 7 +/- 0.2 nm, covering approximately 0.02% of the capillary surface area) that there is no apparent hindrance for molecules as large as raffinose. Infrequent large pores account for the remaining 5% of the flux. During osmotic transients due to 30 mM increases in concentrations of small solutes, the transendothelial water flux was in the opposite direction and almost 800 times as large and was entirely transendothelial because no solute gradient forms across the pores. During albumin transients, gradients persisted for long times because albumin does not permeate small pores; the water fluxes per milliosmolar osmolarity change were 200 times larger than steady-state water flux. The analysis completely reconciles data from osmotic transient, tracer dilution, and lymph sampling techniques.
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