Evidence map›Paper›PMID 12737740›Full record

SynthesisEmerging infectious diseases2003

Global illness and deaths caused by rotavirus disease in children.

Umesh D Parashar, Erik G Hummelman, Joseph S Bresee, Mark A Miller, Roger I Glass

Registry-linked trialOpen access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Emerging infectious diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00767364 (Safety and Immunogenicity of Rotavirus Vaccine), which is not on this map. Cited by 557 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
557citing papers in PubMed, 10 pooled it
52.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00767364 phase1completednot on this mapstarted 2009, after this paper: background citation

Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome: A Pilot Study

TypeinterventionalSponsorChildren's Hospital of MichiganRan2009 to 2013Enrolled8ConditionsShort Bowel SyndromeArmsOral, live, pentavalent rotavirus vaccine, RotaTeq(R)
3 · Its place in the literature

Who cites it

557 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,897 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Occurrence of viruses in sewage sludge: A systematic review.The Science of the total environment · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Racecadotril for acute diarrhoea in children.The Cochrane database of systematic reviews · 2019
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Waterborne diseases and climate change.Nature reviews. Microbiology · 2026
    Review
  20. Article

497 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Umesh D ParasharViral Gastroenteritis Section, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop G04, Atlanta, GA 30333, USA. uap2@cdc.gov
Erik G Hummelman
Joseph S Bresee
Mark A Miller
Roger I Glass
Centers for Disease Control and Prevention · USFogarty International Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To estimate the global illness and deaths caused by rotavirus disease, we reviewed studies published from 1986 to 2000 on deaths caused by diarrhea and on rotavirus infections in children. We assessed rotavirus-associated illness in three clinical settings (mild cases requiring home care alone, moderate cases requiring a clinic visit, and severe cases requiring hospitalization) and death rates in countries in different World Bank income groups. Each year, rotavirus causes approximately 111 million episodes of gastroenteritis requiring only home care, 25 million clinic visits, 2 million hospitalizations, and 352,000-592,000 deaths (median, 440,000 deaths) in children <5 years of age. By age 5, nearly every child will have an episode of rotavirus gastroenteritis, 1 in 5 will visit a clinic, 1 in 65 will be hospitalized, and approximately 1 in 293 will die. Children in the poorest countries account for 82% of rotavirus deaths. The tremendous incidence of rotavirus disease underscores the urgent need for interventions, such as vaccines, particularly to prevent childhood deaths in developing nations.

Indexed as

Global HealthChild, PreschoolDeveloped CountriesDeveloping CountriesDiarrheaFemaleGastroenteritisHospitalizationHumansIncidenceInfantMalePrevalenceRotavirus InfectionsSocioeconomic Factors

Identifiers

PMID12737740
PMCPMC2972763
OpenAlexW2127653958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.