ArticleProceedings. Biological sciences2003
The influence of cellular physiology on the initiation of mutational pathways in Escherichia coli populations.
Article in Proceedings. Biological sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Pathogenicity assessment of Shiga toxin-producingFrontiers in microbiology · 2023Article
- Evolutionary dynamics and structural consequences of de novo beneficial mutations and mutant lineages arising in a constant environment.BMC biology · 2021Article
- The effect of metabolic stress on genome stability of a synthetic biology chassis Escherichia coli K12 strain.Microbial cell factories · 2018Article
- Article
- Metabolism at evolutionary optimal States.Metabolites · 2015Review
- Simple phenotypic sweeps hide complex genetic changes in populations.Genome biology and evolution · 2015Article
- Mutations in global regulators lead to metabolic selection during adaptation to complex environments.PLoS genetics · 2014Article
- Ex uno plures: clonal reinforcement drives evolution of a simple microbial community.PLoS genetics · 2014Article
- Starvation induces phenotypic diversification and convergent evolution in Vibrio vulnificus.PloS one · 2014Article
- Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments.PLoS genetics · 2014Article
- A case of adaptation through a mutation in a tandem duplication during experimental evolution in Escherichia coli.BMC genomics · 2013Article
- The basis of antagonistic pleiotropy in hfq mutations that have opposite effects on fitness at slow and fast growth rates.Heredity · 2013Article
- Culture history and population heterogeneity as determinants of bacterial adaptation: the adaptomics of a single environmental transition.Microbiology and molecular biology reviews : MMBR · 2012Review
- The multiplicity of divergence mechanisms in a single evolving population.Genome biology · 2012Article
- Stock culture heterogeneity rather than new mutational variation complicates short-term cell physiology studies of Escherichia coli K-12 MG1655 in continuous culture.Microbiology (Reading, England) · 2011Article
- Microbial laboratory evolution in the era of genome-scale science.Molecular systems biology · 2011Review
- Trade-off between bile resistance and nutritional competence drives Escherichia coli diversification in the mouse gut.PLoS genetics · 2011Article
- Insertion sequence-driven evolution of Escherichia coli in chemostats.Journal of molecular evolution · 2011Article
- Genomic identification of a novel mutation in hfq that provides multiple benefits in evolving glucose-limited populations of Escherichia coli.Journal of bacteriology · 2010Article
- E Unibus Plurum: genomic analysis of an experimentally evolved polymorphism in Escherichia coli.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The factors affecting the direction of evolutionary pathways and the reproducibility of adaptive responses were investigated under closely related but non-identical conditions. Replicate chemostat cultures of Escherichia coli were compared when adapting to partial or severe glucose limitation. Four independent populations used a reproducible sequence of early mutational changes under both conditions, with rpoS mutations always occurring first before mgl. However, there were interesting differences in the timing of mutational sweeps: rpoS mutations appeared in a clock-like fashion under both partial and severe glucose limitation, while mgl sweeps arose under both conditions but at different times. Interestingly, malT and mlc mutations appeared only under severe limitation. Even though the ancestors were genotypically identical, the semi-differentiated properties of bacteria growing with mild or severe glucose limitation sent the populations in characteristic directions. Mutation supply and the fitness contribution of mutations were estimated and demonstrated to be potential influences in the choice of particular adaptation pathways under severe and mild glucose limitation. Predicting all the mutations fixed in adapting populations is beyond our current understanding of evolutionary processes, but the interplay between ancestor physiology and the initiation of adaptation pathways is demonstrated and definable in bacterial populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.