ArticleThe Biochemical journal2003
The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Structural analysis and molecular dynamics simulation studies of HIV-1 antisense protein predict its potential role in HIV replication and pathogenesis.Frontiers in microbiology · 2023Article
- Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation.Molecular cell · 2022Article
- Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells.Genes & genomics · 2020Article
- Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV.PLoS pathogens · 2020Article
- ETV6 in hematopoiesis and leukemia predisposition.Seminars in hematology · 2017Review
- Review
- Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential.International journal of hematology · 2013Review
- Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain.Journal of molecular biology · 2012Article
- Article
- Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model.PloS one · 2012Article
- Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism.PloS one · 2011Article
- Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia.Diagnostic pathology · 2011Article
- Article
- Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function.Current opinion in immunology · 2010Review
- Regulation of sodium-calcium exchanger activity by creatine kinase under energy-compromised conditions.The Journal of biological chemistry · 2010Article
- C/EBPalpha, do not forget your TIP60.Leukemia · 2008Review
- Article
- Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation.Molecular and cellular biology · 2007Article
- Stability of Nmi protein is controlled by its association with Tip60.Molecular and cellular biochemistry · 2007Article
- Article
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2 authors at 1 institution in 1 country.
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Abstract
The translocation E26 transforming-specific (ETS) leukaemia (TEL), alias the ETS variant (ETV6), gene is expressed in most human tissues and encodes a transcriptional repressor. The TEL gene is involved in more than 40 different chromosomal translocations associated with haematological malignancies. As little is known about the function of intact TEL, we searched for TEL-interacting proteins by yeast two-hybrid screening. Among the interacting partners, we identified the histone acetyltransferase protein Tip60 [60 kDa trans-acting regulatory protein of HIV type 1 (Tat)-interacting protein]. The interaction was reproduced in vitro, and in mammalian cells we mapped the interaction regions in TEL to the ETS domain and those in Tip60 to the MYST ('MOZ, Ybf2/Sas3, SAS2 and Tip60', where MOZ stands for male absent on the first, SAS for something about silencing and Ybf2 for identical with SAS2) region. Detailed analysis of the Tip60 MYST domain by introduction of point mutations revealed that an N-terminal C2HC zinc finger was essential for interaction with TEL. Finally, we showed that Tip60 functions in a reporter system as a co-repressor in TEL-mediated transcription repression.
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