Trial reportEuropean journal of applied physiology2003
Impact of elevated ambient temperatures on the acute immune response to intensive endurance exercise.
Trial report in European journal of applied physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Influence of Sodium Citrate Supplementation after Dehydrating Exercise on Responses of Stress Hormones to Subsequent Endurance Cycling Time-Trial in the Heat.Medicina (Kaunas, Lithuania) · 2019Trial
- No effects of acclimation to heat on immune and hormonal responses to passive heating in healthy volunteers.International journal of biometeorology · 2012Trial
- Relationship between C-reactive protein concentration and cytokine responses to exercise in healthy and illness-prone runners.European journal of applied physiology · 2009Trial
- Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes.Physiological reports · 2025Article
- Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review.The journal of physiological sciences : JPS · 2023Article
- Effect of Flavonoids in Hawthorn and Vitamin C Prevents Hypertension in Rats Induced by Heat Exposure.Molecules (Basel, Switzerland) · 2022Article
- Effect of Multiple-Nutrient Supplement on Muscle Damage, Liver, and Kidney Function After Exercising Under Heat: Based on a Pilot Study and a Randomised Controlled Trial.Frontiers in nutrition · 2021Article
- Higher Temperatures, Higher Solar Radiation, and Less Humidity Is Associated With Poor Clinical and Laboratory Outcomes in COVID-19 Patients.Frontiers in public health · 2021Article
- Resistance Exercise in a Hot Environment Alters Serum Markers in Untrained Males.Frontiers in physiology · 2020Article
- Keeping Athletes Healthy at the 2020 Tokyo Summer Games: Considerations and Illness Prevention Strategies.Frontiers in physiology · 2019Article
- The Impact of Resveratrol Supplementation on Inflammation Induced by Acute Exercise in Rats: Il6 Responses to Exercise.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Exercise-induced changes in skin temperature and blood parameters in horses.Archives animal breeding · 2019Article
- Immune Response in Women during Exercise in the Heat: A Spotlight on Oral Contraception.Journal of sports science & medicine · 2018Article
- Winter ambient training conditions are associated with increased bronchial hyperreactivity and with shifts in serum innate immunity proteins in young competitive speed skaters.Archives of medical science : AMS · 2018Article
- Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment.Oxidative medicine and cellular longevity · 2018Article
- Inflammatory responses of older firefighters to intermittent exercise in the heat.European journal of applied physiology · 2014Article
- The effects of cold exposure on leukocytes, hormones and cytokines during acute exercise in humans.PloS one · 2014Article
- Running a marathon from -45°C to +55°C in a climate chamber: a case study.Open access journal of sports medicine · 2012Article
- A comparison of cytokine responses during prolonged cycling in normal and hot environmental conditions.Open access journal of sports medicine · 2011Article
- Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise.European journal of applied physiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, there has been little research examining how elevated ambient temperatures exert an additional effect on the acute immune response to endurance exercise. Seven endurance-trained, non-heat-acclimated men [mean (95% confidence interval): 29.7 (25.9-33.5) years, .VO(2max) 66.3 (61.3-71.3) ml.kg(-1).min(-1)] performed two 60-min treadmill runs (75% .VO(2max)) in two different environments (EX1: 18 degrees C/50% room temperature/relative humidity and EX2: 28 degrees C/50% room temperature/relative humidity) with a 7-day interval between the runs. Blood samples were drawn at rest and 0, 0.5, 3, 24, and 48 h after exercise. Compared to EX1, exercise-induced increases in core temperature, sweating rate, heart rate, plasma norepinephrine, cortisol, human growth hormone, and neutrophil and monocyte counts were significantly (5% level) more pronounced after EX2. In contrast, responses of plasma epinephrine, myeloperoxidase, interleukin (IL)-6 as well as lymphocyte counts were similar in EX1 and EX2. Plasma concentrations of IL-8 and C-reactive protein were affected by neither exercise nor by additional heat exposure. Our results suggest that the additional impact of elevated ambient temperatures on stress responses to endurance exercise in trained subjects seems to affect primarily the cardiocirculatory and hormonal systems, and resulting changes in neutrophil and monocyte cell-trafficking. In contrast, heat stress does not seem to exert large additional effects on the acute immune response to endurance exercise as performed in the present study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.