Trial reportEuropean journal of applied physiology2003
Oxygen uptake kinetics during moderate, heavy and severe intensity "submaximal" exercise in humans: the influence of muscle fibre type and capillarisation.
Trial report in European journal of applied physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 71 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed.
- Analysis of cardio-pulmonary and respiratory kinetics in different body positions: impact of venous return on pulmonary measurements.European journal of applied physiology · 2016Trial
- Mechanisms of Attenuation of Pulmonary V'O2 Slow Component in Humans after Prolonged Endurance Training.PloS one · 2016Trial
- Trial
- Exercise intensity and oxygen uptake kinetics in African-American and Caucasian women.European journal of applied physiology · 2012Trial
- Trial
- Kinetics of oxygen uptake during arm cranking with the legs inactive or exercising at moderate intensities.European journal of applied physiology · 2005Trial
- The VO2 response for an exhaustive treadmill run at 800-m pace: a breath-by-breath analysis.European journal of applied physiology · 2005Trial
- Sex differences in the oxygen uptake kinetic response to heavy-intensity exercise in prepubertal children.European journal of applied physiology · 2004Trial
- The slow component of VO(2) kinetics in very heavy and fatiguing square-wave exercise.European journal of applied physiology · 2004Trial
- Influence of muscle fibre type and pedal rate on the VO2-work rate slope during ramp exercise.European journal of applied physiology · 2004Trial
- Sex Differences in Durability Following Heavy Intensity Cycling Exercise in Trained Athletes.Scandinavian journal of medicine & science in sports · 2026Article
- Changes in intramuscular blood flow and muscle deoxygenation at different parts of the vastus lateralis during intermittent isometric knee extension in young adult males.Physiological reports · 2026Article
- Resistance exercise training similarly improves work efficiency and measured submaximal oxygen consumption during the 6-min walk test in healthy postmenopausal women and breast cancer survivors.European journal of applied physiology · 2026Article
- Assessing lactate stability at the minimum lactate steady state velocity in male trained middle-distance runners.PloS one · 2026Article
- Skeletal muscle mitochondrial correlates of critical power and W' in healthy active individuals.Experimental physiology · 2025Article
- Physiological Correspondence Between Different Indexes of High-Intensity Endurance Exercise in Young Male Runners.Sports (Basel, Switzerland) · 2025Article
- Exercise Pulmonary Hypertension and Beyond: Insights in Exercise Pathophysiology in Pulmonary Arterial Hypertension (PAH) from Invasive Cardiopulmonary Exercise Testing.Journal of clinical medicine · 2025Review
- Olympic distance duathlon and cardiac performance in highly-trained triathletes.Physiological reports · 2024Article
- Substrate utilization and durability during prolonged intermittent exercise in elite road cyclists.European journal of applied physiology · 2024Article
- No sex differences in oxygen uptake or extraction kinetics in the moderate or heavy exercise intensity domains.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedSakkas, Giorkos K [added]
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the present study was to test the hypothesis that muscle fibre type influences the oxygen uptake (.VO(2)) on-kinetic response (primary time constant; primary and slow component amplitudes) during moderate, heavy and severe intensity sub-maximal cycle exercise. Fourteen subjects [10 males, mean (SD) age 25 (4) years; mass 72.6 (3.9) kg; .VO(2peak) 47.9 (2.3) ml kg(-1) min(-1)] volunteered to participate in this study. The subjects underwent a muscle biopsy of the vastus lateralis for histochemical determination of muscle fibre type, and completed repeat "square-wave" transitions from unloaded cycling to power outputs corresponding to 80% of the ventilatory threshold (VT; moderate exercise), 50% (heavy exercise) and 70% (severe exercise) of the difference between the VT and .VO(2peak). Pulmonary .VO(2) was measured breath-by-breath. The percentage of type I fibres was significantly correlated with the time constant of the primary .VO(2) response for heavy exercise (r=-0.68). Furthermore, the percentage of type I muscle fibres was significantly correlated with the gain of the .VO(2) primary component for moderate (r=0.65), heavy (r=0.57) and severe (r=0.57) exercise, and with the relative amplitude of the .VO(2) slow component for heavy (r=-0.74) and severe (r=-0.64) exercise. The influence of muscle fibre type on the .VO(2) on-kinetic response persisted when differences in aerobic fitness and muscle capillarity were accounted for. This study demonstrates that muscle fibre type is significantly related to both the speed and the amplitudes of the .VO(2) response at the onset of constant-load sub-maximal exercise. Differences in contraction efficiency and oxidative enzyme activity between type I and type II muscle fibres may be responsible for the differences observed.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.