ArticleHistochemistry and cell biology2003
The expression of platelet endothelial cell adhesion molecule-1 in mouse primordial germ cells during their migration and early gonadal formation.
Article in Histochemistry and cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues.Development (Cambridge, England) · 2023Article
- Specific Transcriptomic Signatures and Dual Regulation of Steroidogenesis Between Fetal and Adult Mouse Leydig Cells.Frontiers in cell and developmental biology · 2021Article
- Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.eLife · 2019Article
- PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition.Nature communications · 2015Article
- Article
- Dynamic expression of Tbx2 subfamily genes in development of the mouse reproductive system.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Return to the hematopoietic stem cell origin.Cell regeneration (London, England) · 2012Review
- Direct effects of retinoic acid on entry of fetal male germ cells into meiosis in mice.Biology of reproduction · 2010Article
- Neutralization of vascular endothelial growth factor antiangiogenic isoforms or administration of proangiogenic isoforms stimulates vascular development in the rat testis.Reproduction (Cambridge, England) · 2010Article
- Intact fetal ovarian cord formation promotes mouse oocyte survival and development.BMC developmental biology · 2010Article
- Expression, localization, and binding activity of the ezrin/radixin/moesin proteins in the mouse testis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Vascular endothelial growth factor and kinase domain region receptor are involved in both seminiferous cord formation and vascular development during testis morphogenesis in the rat.Biology of reproduction · 2006Article
- Differences in platelet endothelial cell adhesion molecule-1 expression between peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis.World journal of gastroenterology · 2005Article
- News and views in Histochemistry and Cell Biology.Histochemistry and cell biology · 2004Review
- Innovative techniques and applications in histochemistry and cell biology.Histochemistry and cell biology · 2003Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The platelet endothelial cell adhesion molecule-1 (PECAM-1), or CD31, a member of the immunoglobulin superfamily, is located on the plasma membrane of endothelial and hematopoietic cells and involved in vascular development and inflammation. In this study, by use of immunohistochemistry at light and electron microscopic levels in combination with enzyme histochemistry for alkaline phosphatase, we demonstrated that PECAM-1/CD31 is expressed in the mouse primordial germ cell (PGC). Up to 8 days postcoitum (dpc), PGCs with alkaline phosphatase activity showed no PECAM-1/CD31 immunoreactivity. At 9 dpc, PECAM-1/CD31 immunoreactivity was first detected with low intensity in some PGCs located in the hindgut. Between 10 and 11 dpc, intense immunoreactivity was shown on the entire surface of PGCs migrating along the dorsal wall. After arrival and settlement of PGCs in the genital ridges around 11.5 dpc, the intense immunoreactivity was maintained on the entire surface of PGCs. By electron microscopy, the immunoreactivity was localized exclusively on the plasma membrane of PGCs, being as strong at the portions adjacent to neighboring PGCs as those adjacent to somatic cells. As the male and female gonads began to differentiate, PECAM-1/CD31 immunoreactivity remained strong in germ cells until 13 dpc, after which it gradually decreased in intensity and disappeared by 16 dpc. These results suggested that cell-to-cell interaction through PECAM-1/CD31 plays roles in the development of PGCs during their migration on the dorsal wall and homing in the gonads.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.