ArticleNucleic acids research2003
Limited microsynteny between the genomes of Pristionchus pacificus and Caenorhabditis elegans.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Visualizing genomic evolution in Caenorhabditis through WormSynteny.BMC genomics · 2024Article
- Nematode chromosomes.Genetics · 2022Review
- Genus-level evolutionary relationships of FAR proteins reflect the diversity of lifestyles of free-living and parasitic nematodes.BMC biology · 2021Article
- Sex chromosome evolution in parasitic nematodes of humans.Nature communications · 2020Article
- Genome Architecture and Evolution of a Unichromosomal Asexual Nematode.Current biology : CB · 2017Article
- Article
- Characterization of genetic diversity in the nematode Pristionchus pacificus from population-scale resequencing data.Genetics · 2014Article
- The draft genome of the parasitic nematode Trichinella spiralis.Nature genetics · 2011Article
- The genome of Brugia malayi - all worms are not created equal.Parasitology international · 2009Review
- Genes encoding putative biogenic amine receptors in the parasitic nematode Brugia malayi.Invertebrate neuroscience : IN · 2007Article
- Draft genome of the filarial nematode parasite Brugia malayi.Science (New York, N.Y.) · 2007Article
- Comparison of C. elegans and C. briggsae genome sequences reveals extensive conservation of chromosome organization and synteny.PLoS biology · 2007Article
- Improving the Caenorhabditis elegans genome annotation using machine learning.PLoS computational biology · 2007Article
- Pristionchus.org: a genome-centric database of the nematode satellite species Pristionchus pacificus.Nucleic acids research · 2007Article
- Conservation of the global sex determination gene tra-1 in distantly related nematodes.Genes & development · 2004Article
- Evolution of dnmt-2 and mbd-2-like genes in the free-living nematodes Pristionchus pacificus, Caenorhabditis elegans and Caenorhabditis briggsae.Nucleic acids research · 2004Article
- An integrated physical and genetic map of the nematode Pristionchus pacificus.Molecular genetics and genomics : MGG · 2003Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nematodes are an attractive group of organisms for studying the evolution of developmental processes. Pristionchus pacificus was established as a satellite organism for comparing vulva development and other processes to Caenorhabditis elegans. The generation of a genetic linkage map of P.pacificus has provided a first insight into the structure and organization of the genome of this species. Pristionchus pacificus and C.elegans are separated from one another by >100 000 000 years such that the structure of the genomes of these two nematodes might differ substantially. To evaluate the amount of synteny between the two genomes, we have obtained 126 kb of continuous genomic sequence of P.pacificus, flanking the developmental patterning gene pal-1. Of the 20 predicted open reading frames in this interval, 11 have C.elegans orthologs. Ten of these 11 orthologs are located on C.elegans chromosome III, indicating the existence of synteny. However, most of these genes are distributed over a 12 Mb interval of the C.elegans genome and only three pairs of genes show microsynteny. Thus, intrachromosomal rearrange ments occur frequently in nematodes, limiting the likelihood of identifying orthologous genes of P.pacificus and C.elegans based on positional information within the two genomes.
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