ArticleNucleic acids research2003
RRP20, a component of the 90S preribosome, is required for pre-18S rRNA processing in Saccharomyces cerevisiae.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
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- Knockdown of PNO1 inhibits esophageal cancer progression.Oncology reports · 2021Article
- PNO1, which is negatively regulated by miR-340-5p, promotes lung adenocarcinoma progression through Notch signaling pathway.Oncogenesis · 2020Article
- Ribosome Biogenesis in Plants: From Functional 45S Ribosomal DNA Organization to Ribosome Assembly Factors.The Plant cell · 2019Review
- Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis.PLoS genetics · 2014Article
- Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast.The Journal of biological chemistry · 2014Article
- Pno1 tissue-specific expression and its functions related to the immune responses and proteasome activities.PloS one · 2012Article
- Roles of Dim2 in ribosome assembly.The Journal of biological chemistry · 2011Article
- TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export.RNA (New York, N.Y.) · 2008Article
- Staying alive in adversity: transcriptome dynamics in the stress-resistant dauer larva.Functional & integrative genomics · 2006Article
- Role for RNA-binding proteins implicated in pathogenic development of Ustilago maydis.Eukaryotic cell · 2005Article
- A system for enhancing genome-wide coexpression dynamics study.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- PIN domain of Nob1p is required for D-site cleavage in 20S pre-rRNA.RNA (New York, N.Y.) · 2004Article
- Dim2p, a KH-domain protein required for small ribosomal subunit synthesis.RNA (New York, N.Y.) · 2004Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A strain of Saccharomyces cerevisiae, defective in small subunit ribosomal RNA processing, has a mutation in YOR145c ORF that converts Gly235 to Asp. Yor145c is a nucleolar protein required for cell viability and has been reported recently to be present in 90S pre-ribosomal particles. The Gly235Asp mutation in YOR145c is found in a KH-type RNA-binding domain and causes a marked deficiency in 18S rRNA production. Detailed studies by northern blotting and primer extension analyses show that the mutant strain impairs the early pre-rRNA processing cleavage essentially at sites A1 and A2, leading to accumulation of a 22S dead-end processing product that is found in only a few rRNA processing mutants. Furthermore, U3, U14, snR10 and snR30 snoRNAs, involved in early pre-rRNA cleavages, are not destabilized by the YOR145c mutation. As the protein encoded by YOR145c is found in pre-ribosomal particles and the mutant strain is defective in ribosomal RNA processing, we have renamed it as RRP20.
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