ArticleJournal of cancer research and clinical oncology2003
Allelic imbalance regions on chromosomes 8p, 17p and 19p related to metastasis of hepatocellular carcinoma: comparison between matched primary and metastatic lesions in 22 patients by genome-wide microsatellite analysis.
Article in Journal of cancer research and clinical oncology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Biomarker in Hepatocellular Carcinoma.Indian journal of surgical oncology · 2024Review
- The Role of Circulating Free DNA and MicroRNA in Non-Invasive Diagnosis of HBV- and HCV-Related Hepatocellular Carcinoma.International journal of molecular sciences · 2018Review
- Circulating tumor DNA in hepatocellular carcinoma: trends and challenges.Cell & bioscience · 2016Review
- Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma.Oncogene · 2012Article
- Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.Nature cell biology · 2010Article
- Molecular genetics of hepatocellular neoplasia.American journal of translational research · 2010Article
- Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling.The Journal of clinical investigation · 2010Article
- Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: preliminary study.BMC research notes · 2008Article
- Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.Journal of gastroenterology · 2008Article
- Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma.BMC cancer · 2007Article
- The role of estrogen in the initiation of breast cancer.The Journal of steroid biochemistry and molecular biology · 2006Review
- Hepatocellular carcinoma pathogenesis: from genes to environment.Nature reviews. Cancer · 2006Review
- The prognostic value of circulating plasma DNA level and its allelic imbalance on chromosome 8p in patients with hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2006Article
- HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma.Oncogene · 2006Article
- Molecular profiling of hepatocellular carcinomas by cDNA microarray.World journal of gastroenterology · 2005Review
- Recent progress in predictive biomarkers for metastatic recurrence of human hepatocellular carcinoma: a review of the literature.Journal of cancer research and clinical oncology · 2004Review
- A decade's studies on metastasis of hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2004Review
- The abnormalities of chromosome 8 in two hepatocellular carcinoma cell clones with the same genetic background and different metastatic potential.Journal of cancer research and clinical oncology · 2003Article
- Chromosomal aberrations related to metastasis of human solid tumors.World journal of gastroenterology · 2002Review
- The prognostic molecular markers in hepatocellular carcinoma.World journal of gastroenterology · 2002Review
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the molecular mechanisms of metastasis in hepatocellular carcinoma (HCC), it is necessary to identify the accumulating genetic alterations during its progression as well as those responsible for the acquisition of metastatic potential in cancer cells. In our previous study, using comparative genomic hybridization (CGH), we found that loss on chromosome 8p is more frequent in metastatic lesions than in matched primary tumors of HCC. Thus, 8p deletion might contribute to HCC metastasis. To narrow the location of metastasis-related alteration regions, we analyzed 22 primary and matched metastatic lesions of HCC by genome-wide microsatellite analysis. Common regions with high levels of allelic imbalance (AI) were identified on 17p, 8p11-cen, 8p21-23, 4q32-qter, 4q13-23, 16q, and 1p33. Regions with increased AI in metastatic lesions were 8p23.3, 8p11.2, 17p11.2-13.3, 4q21-22, 4q32-qter, 8q24.1, 9p11, 9q31, 11q23.1, 13q14.1-31, 13q32-qter, 16p13.3, 16q13, 16q22, and 19p13.1, and these were considered to be related to the metastasis phenotype. Among them, loss on 8p was again proved to be related to progression and metastasis of HCC, and 8p23.3 and 8p11.2 were two likely regions harboring metastasis-related genes. It was also shown for the first time in HCC that AI of 19p13.1 might also be related to metastatic potential. These results provide some candidate regions for further study to identify putative genes suppressing metastasis of HCC.
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