ArticleInternational journal of legal medicine2003
Sequence polymorphisms within the human mitochondrial genes MTATP6, MTATP8 and MTND4.
Article in International journal of legal medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Forensic mass screening using mtDNA.International journal of legal medicine · 2006Article
- V-MitoSNP: visualization of human mitochondrial SNPs.BMC bioinformatics · 2006Article
- Effective strategies for forensic analysis in the mitochondrial DNA coding region.International journal of legal medicine · 2006Article
- Artificial recombination in forensic mtDNA population databases.International journal of legal medicine · 2004Article
- Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.International journal of legal medicine · 2004Article
- A parent-of-origin detectable polymorphism in the hypermethylated region upstream of the human H19 gene.International journal of legal medicine · 2004Article
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Authors and funding
4 authors.
Funding
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Abstract
By sequencing the control region of mitochondrial DNA, the majority of human DNA samples can be differentiated. A further increase in differentiation probability may be possible, e.g. by extending the sequenced region to coding regions of the mitochondrial genome. Restriction to those positions that do not result in a change of the amino acids guarantees that the information thus obtained does not refer to phenotypically relevant information. In the present study the sequence data of the mitochondrial genes MTATP6, MTATP8 and MTND4 were collected from 109 subjects and analyzed in order to define variable positions suitable for identification purposes. There were 32 variable base positions among 850 bases studied from MTATPase genes and 1,200 bases of the MTND4 gene showed 28 variable positions. "Hot spots" for base exchanges were found in both regions and one position (position 11,719 in the MTND4 gene) seems to be suitable for SNP investigation for forensic purposes.
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