Evidence map›Paper›PMID 12734577›Full record

ArticleBiological procedures online2002

Methods for the study of ionic currents and Ca2+-signals in isolated colonic crypts.

Gerhard Schultheiss, Sarah Lan Kocks, Martin Diener

Abstract read
In one paragraph

Article in Biological procedures online, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. The ZnBiochimica et biophysica acta. Molecular basis of disease · 2017
    Article
  2. Novel aspects of cholinergic regulation of colonic ion transport.Pharmacology research & perspectives · 2015
    Article
  3. ATP-sensitive K(+) channels in rat colonic epithelium.Pflugers Archiv : European journal of physiology · 2013
    Article
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  10. Stimulation of colonic anion secretion by monochloramine: action sites.Pflugers Archiv : European journal of physiology · 2005
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gerhard SchultheissInstitut für Veterinär-Physiologie, Justus-Liebig-Universität. Prof. Dr. M. Diener, Institut für Veterinär-Physiologie, Universität Giessen, Frankfurter Str. 100, D-35392 Giessen. Germany. Martin.Diener@vetmed.uni-giessen.de
Sarah Lan Kocks
Martin Diener

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isolated epithelial cells from intestinal mucosae are a suitable object for the study of the regulation of ion transport in the gut. This regulation possesses a great importance for human and veterinary medicine, as diarrheal diseases, which often are caused by an inadequate activation of intestinal anion secretion, are one of the major lethal diseases of children or young animals. The aim of this paper is to describe a method for the isolation of intact colonic crypts, e.g. for the subsequent investigation of the regulation of anion secretion by the intracellular second messenger, Ca(2+) using electrophysiological and imaging techniques.

Identifiers

PMID12734577
PMCPMC145548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.