ReviewJournal of biosciences2003
Molecular interactions of 'high risk' human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression.
Review in Journal of biosciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Differentially Expressed Genes Associated with the Development of Cervical Cancer.International journal of molecular sciences · 2025Article
- The role of HR-HPV integration in the progression of premalignant lesions into different cancer types.Heliyon · 2024Review
- Increased expression of HPV-E7 oncoprotein correlates with a reduced level of pRb proteins via high viral load in cervical cancer.Scientific reports · 2023Article
- Human Papillomaviruses and Epstein-Barr Virus Interactions in Colorectal Cancer: A Brief Review.Pathogens (Basel, Switzerland) · 2020Review
- Frequency of Human papillomavirus in women attending cervical cancer screening program in Chile.BMC cancer · 2017Article
- Local administration of siRNA through Microneedle: Optimization, Bio-distribution, Tumor Suppression and Toxicity.Scientific reports · 2016Article
- Multistep model of cervical cancer: participation of miRNAs and coding genes.International journal of molecular sciences · 2014Review
- Solution structure analysis of the HPV16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53.Structure (London, England : 1993) · 2012Article
- Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells.Oncogene · 2012Article
- Preventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers.Iranian journal of basic medical sciences · 2012Article
- Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6.Protein expression and purification · 2011Article
- Human papillomavirus DNA and oncogene alterations in colorectal tumors.Pathology oncology research : POR · 2010Article
- IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes.Experimental dermatology · 2010Article
- Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells.Molecular and cellular biochemistry · 2009Article
- Koilocytosis: a cooperative interaction between the human papillomavirus E5 and E6 oncoproteins.The American journal of pathology · 2008Article
- Cellular binding partners of the human papillomavirus E6 protein.Archives of virology · 2008Review
- Silencing of integrated human papillomavirus type 18 oncogene transcription in cells expressing SerpinB2.Journal of virology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aetiology of cervical cancer has been primarily attributed to human papillomaviruses (HPVs). These are characterized by the persistent expression of the two oncogenes, E6 and E7. Experimental studies show that E6 and E7 genes of the high risk HPVs deregulate key cell cycle controls. Recent work has uncovered new cellular partners for these proteins that throw light on many of the pathways and processes in which these viral proteins intervene. This review focuses on the regulation of host proteins by the viral oncoproteins and consequence of such interactions on cell survival, proliferation, differentiation and apoptosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.