ReviewGene therapy2003
Gene therapy for arthritis.
Review in Gene therapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 118 citations in OpenAlex.
- Genetics in Cartilage Lesions: Basic Science and Therapy Approaches.International journal of molecular sciences · 2020Review
- Non-viral Gene Therapy for Osteoarthritis.Frontiers in bioengineering and biotechnology · 2020Review
- Rheumatiod Arthritis: An Updated Overview of Latest Therapy and Drug Delivery.Journal of pharmacopuncture · 2019Review
- Lactobacillus acidophilus Protected Organs in Experimental Arthritis by Regulating the Pro-inflammatory Cytokines.Indian journal of clinical biochemistry : IJCB · 2014Article
- Stem cells and gene therapy for cartilage repair.Stem cells international · 2012Article
- Immunosuppressive exosomes: a new approach for treating arthritis.International journal of rheumatology · 2012Article
- Gene Therapy for Cartilage Repair.Cartilage · 2011Review
- Current advances in retroviral gene therapy.Current gene therapy · 2011Review
- Clinical potential and challenges of using genetically modified cells for articular cartilage repair.Croatian medical journal · 2011Review
- Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model.Tissue engineering. Part B, Reviews · 2010Review
- Concepts in gene therapy for cartilage repair.Injury · 2008Review
- Mechanisms modulating inflammatory osteolysis: a review with insights into therapeutic targets.Pathology, research and practice · 2008Review
- Major biological obstacles for persistent cell-based regeneration of articular cartilage.Arthritis research & therapy · 2007Review
- Local gene transfer to calcified tissue cells using prolonged infusion of a lentiviral vector.Gene therapy · 2006Article
- Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations.Gene therapy · 2006Article
- Application of cellular gene therapy for rheumatoid arthritis.Modern rheumatology · 2006Review
- Regulated and constitutive expression of anti-inflammatory cytokines by nontransforming herpesvirus saimiri vectors.Gene therapy · 2005Article
- Gene therapy for arthritis--where do we stand?Arthritis research & therapy · 2005Article
- Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoy.Gene therapy · 2004Article
- Prevention of experimental autoimmune encephalomyelitis in DA rats by grafting primary skin fibroblasts engineered to express transforming growth factor-beta1.Clinical and experimental immunology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis is an autoimmune disease with intra-articular inflammation and synovial hyperplasia that results in progressive degradation of cartilage and bone, in severe cases it causes systemic complications. Recently, biological agents that suppress the activities of proinflammatory cytokines have shown efficacy as antiarthritic drugs, but require frequent administration. Thus, gene transfer approaches are being developed as an alternative approach for targeted, more efficient and sustained delivery of inhibitors of inflammatory cytokines as well as other therapeutic agents. Indeed, the efficacy of gene transfer for the treatment of arthritis has been demonstrated in mouse, rat, rabbit, and horse models of disease whereas the feasibility of the approach has been demonstrated in Phase I clinical trials. In this review, the current status of both preclinical and clinical arthritis gene therapy is presented. In addition, the advantages and disadvantages of different types of vectors, target cells and therapeutic genes being developed for the treatment of arthritis are summarized. Finally, the future directions of the rapidly developed field of arthritis gene therapy are outlined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.