ReviewCurrent opinion in biotechnology2003
Plant cell factories and mucosal vaccines.
Review in Current opinion in biotechnology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Edible Vaccines: A Patent-Driven Exploration of Immunization Technologies.Recent patents on biotechnology · 2025Review
- A Comprehensive Overview on the Production of Vaccines in Plant-Based Expression Systems and the Scope of Plant Biotechnology to Combat against SARS-CoV-2 Virus Pandemics.Plants (Basel, Switzerland) · 2021Review
- Genes involved in the endoplasmic reticulum N-glycosylation pathway of the red microalga Porphyridium sp.: a bioinformatic study.International journal of molecular sciences · 2014Article
- An interspecific Nicotiana hybrid as a useful and cost-effective platform for production of animal vaccines.PloS one · 2012Article
- Use of GFP to investigate expression of plant-derived vaccines.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Expression of cholera toxin B subunit in transgenic rice endosperm.Molecular biotechnology · 2008Article
- Production of recombinant allergens in plants.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2008Article
- Sustained expression of human cytomegalovirus glycoprotein B (UL55) in the seeds of homozygous rice plants.Molecular biotechnology · 2008Article
- Expression of toxin co-regulated pilus subunit A (TCPA) of Vibrio cholerae and its immunogenic epitopes fused to cholera toxin B subunit in transgenic tomato (Solanum lycopersicum).Plant cell reports · 2008Article
- Biologically active human GM-CSF produced in the seeds of transgenic rice plants.Transgenic research · 2007Article
- Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms.Annals of the New York Academy of Sciences · 2007Review
- Pharma-Planta: road testing the developing regulatory guidelines for plant-made pharmaceuticals.Transgenic research · 2007Review
- Agroinjection of tomato fruits. A tool for rapid functional analysis of transgenes directly in fruit.Plant physiology · 2006Article
- Expression of functional interleukin-12 from mouse in transgenic tomato plants.Transgenic research · 2005Article
- Inducible expression in plants by virus-mediated transgene activation.Transgenic research · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many advances continue to be made in the field of plant-derived vaccines. Plants have been shown capable of expressing a multicomponent vaccine that when orally delivered induces a T-helper cell subset 1 response and enables passive immunization. Furthermore, a plant-derived vaccine has been shown to protect against challenge in the target host. Increased antigen expression levels (up to 4.1% total soluble protein) have been obtained through transformation of the chloroplast genome. In view of these findings, plant-derived vaccines have been proved as valuable commodities to the world's health system; however, before their application, studies need to focus on optimization of immunization strategies and to investigate antigen stability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.