ArticleJournal of human genetics2003
Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects.
Article in Journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- "Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".Metabolic brain disease · 2015Pooled it
- Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature.PloS one · 2013Pooled it
- Pooled it
- Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase.Nature communications · 2024Article
- Metabolic Analysis of Methylenetetrahydrofolate Reductase Single Nucleotide Polymorphisms (MTHFR 677C<T and MTHFR 1298A<C), Serum Folate and Vitamin B12 in Neural Tube Defects.Indian journal of clinical biochemistry : IJCB · 2023Article
- Polymorphisms in Maternal Selected Folate Metabolism-Related Genes in Neural Tube Defect-Affected Pregnancy.Advanced biomedical research · 2023Article
- Folate Pathway Gene Single Nucleotide Polymorphisms and Neural Tube Defects: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2022Review
- No evidence for association ofClinical epigenetics · 2018Article
- Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring.Metabolic brain disease · 2015Article
- Neural tube defects, folic acid and methylation.International journal of environmental research and public health · 2013Review
- Folate-related gene variants in Irish families affected by neural tube defects.Frontiers in genetics · 2013Article
- Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects.BMC medical genetics · 2012Article
- Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population.American journal of medical genetics. Part A · 2011Article
- Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.Birth defects research. Part A, Clinical and molecular teratology · 2010Article
- The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects.Birth defects research. Part A, Clinical and molecular teratology · 2009Review
- Testing for genetic association with constrained models using triads.Annals of human genetics · 2009Article
- Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.Birth defects research. Part A, Clinical and molecular teratology · 2008Article
- Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene.Journal of medical genetics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The thermolabile variant (677TT) of methylenetetrahydrofolate reductase (MTHFR) is a known risk factor for neural tube defects (NTDs). The relationship between a second MTHFR polymorphism (1298A-->C) and NTD risk has been inconsistent between studies. We genotyped 276 complete NTD triads (mother, father and child affected with an NTD) and 256 controls for MTHFR 1298A-->C. Our findings do not support a role for the 1298A-->C polymorphism in NTDs (OR 0.85 (95% CI 0.49-1.47), p= 0.55), nor do we observe a combined effect with the 677C-->T polymorphism.
Indexed as
Identifiers
12730722What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.