Evidence map›Paper›PMID 12730672›Full record

ArticleOncogene2003

Physical and functional interaction between HCV core protein and the different p73 isoforms.

Anna Alisi, Stefania Giambartolomei, Felicia Cupelli, Paola Merlo, Giulia Fontemaggi, Alessandra Spaziani, Clara Balsano

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Current Perspectives in Immunotherapy for Liver Cancer.Critical reviews in oncogenesis · 2020
    Article
  6. Review
  7. Review
  8. Review
  9. Hepatitis C virus-induced hepatocellular carcinoma.Clinical and molecular hepatology · 2015
    Review
  10. Review
  11. Review
  12. Article
  13. Hepatitis C virus and hepatocarcinogenesis.Clinical and molecular hepatology · 2012
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. p73-Binding Partners and Their Functional Significance.International journal of proteomics · 2010
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anna AlisiFondazione Andrea Cesalpino, I Clinica Medica, V.le del Policlinico 155, 00161 Roma, Italy.
Stefania Giambartolomei
Felicia Cupelli
Paola Merlo
Giulia Fontemaggi
Alessandra Spaziani
Clara Balsano
Fondazione Andrea Cesalpino · ITUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus (HCV) core protein is a structural viral protein that packages the viral genomic RNA. In addition to this function, HCV core also modulates a number of cellular regulatory functions. In fact, HCV core protein has been found to modulate the expression of the cyclin-dependent inhibitor p21(WAF1/CIP1) and to promote both apoptosis and cell proliferation through its physical interaction with p53. Here, we studied the ability of HCV core to bind the p53-related p73 protein, its isoforms and its deletion mutants. We found that HCV core co-immunoprecipitated with p73 in HepG2 and SAOS-2 cells. Deletion mutational analysis of p73 indicates that the domain involved in HCV core binding is located between amino-acid residues 321-353. We also demonstrate that p73/core interaction results in the nuclear translocation of HCV core protein either in the presence of the p73 alpha or p73 beta tumor-suppressor proteins. In addition, the interaction with HCV core protein prevents p73 alpha, but not p73 beta dependent cell growth arrest in a p53-dependent manner. Our findings demonstrate that HCV core protein may directly influence the various p73 functions, thus playing a role in HCV pathogenesis.

Indexed as

Active Transport, Cell NucleusCarcinoma, HepatocellularCyclin-Dependent Kinase Inhibitor p21CyclinsDNA-Binding ProteinsGenes, Tumor SuppressorHumansIn Vitro TechniquesNuclear ProteinsOsteosarcomaPromoter Regions, GeneticProtein IsoformsTumor Cells, CulturedTumor Protein p73Tumor Suppressor Protein p53Tumor Suppressor ProteinsCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21CyclinsDNA-Binding ProteinsNuclear Proteinsnucleocapsid protein, Hepatitis C virusProtein IsoformsTP73 protein, humanTumor Protein p73Tumor Suppressor Protein p53Tumor Suppressor ProteinsViral Core Proteins

Identifiers

PMID12730672
OpenAlexW1973722378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.