ArticleThe Journal of physiology2003
Development of synchronized activity of cranial motor neurons in the segmented embryonic mouse hindbrain.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Metallothionein III Mediates CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Tetrodotoxin-resistant mechanosensitivity and L-type calcium channel-mediated spontaneous calcium activity in enteric neurons.Experimental physiology · 2024Article
- Suckling, Feeding, and Swallowing: Behaviors, Circuits, and Targets for Neurodevelopmental Pathology.Annual review of neuroscience · 2020Review
- Persistent Sodium Current Drives Excitability of Immature Renshaw Cells in Early Embryonic Spinal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Development of Spontaneous Activity in the Avian Hindbrain.Frontiers in neural circuits · 2016Review
- Regulation of Spontaneous Propagating Waves in the Embryonic Mouse Brainstem.Frontiers in neural circuits · 2016Article
- In vivo Calcium Imaging of Evoked Calcium Waves in the Embryonic Cortex.Frontiers in cellular neuroscience · 2015Article
- Relationship between individual neuron and network spontaneous activity in developing mouse cortex.Journal of neurophysiology · 2014Article
- Acetylcholine controls GABA-, glutamate-, and glycine-dependent giant depolarizing potentials that govern spontaneous motoneuron activity at the onset of synaptogenesis in the mouse embryonic spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Hyperpolarization of resting membrane potential causes retraction of spontaneous Ca(i)²⁺ transients during mouse embryonic circuit development.The Journal of physiology · 2013Article
- Large-scale synchronized activity in the embryonic brainstem and spinal cord.Frontiers in cellular neuroscience · 2013Article
- Early development of electrical excitability in the mouse enteric nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Emergence of patterned activity in the developing zebrafish spinal cord.Current biology : CB · 2012Article
- Early emergence of neural activity in the developing mouse enteric nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Developmental changes in propagation patterns and transmitter dependence of waves of spontaneous activity in the mouse cerebral cortex.The Journal of physiology · 2011Article
- Population calcium imaging of spontaneous respiratory and novel motor activity in the facial nucleus and ventral brainstem in newborn mice.The Journal of physiology · 2011Article
- Maturation of synaptic partners: functional phenotype and synaptic organization tuned in synchrony.The Journal of physiology · 2010Article
- Mechanisms underlying spontaneous patterned activity in developing neural circuits.Nature reviews. Neuroscience · 2010Review
- Differential expression of membrane conductances underlies spontaneous event initiation by rostral midline neurons in the embryonic mouse hindbrain.The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous electrical activity synchronized among groups of related neurons is a widespread and important feature of central nervous system development. Among the many places from which spontaneous rhythmic activity has been recorded early in development are the cranial motor nerve roots that exit the hindbrain, the motor neuron pool that, at birth, will control the rhythmic motor patterns of swallow, feeding and the oral components of respiratory behaviour. Understanding the mechanism and significance of this hindbrain activity, however, has been hampered by the difficulty of identifying and recording from individual hindbrain motor neurons in living tissue. We have used retrograde labelling to identify living cranial branchiomeric motor neurons in the hindbrain, and [Ca2+]i imaging of such labelled cells to measure spontaneous activity simultaneously in groups of motor neuron somata. We find that branchiomeric motor neurons of the trigeminal and facial nerves generate spontaneous [Ca2+]i transients throughout the developmental period E9.5 to E11.5. During this two-day period the activity changes from low-frequency, long-duration events that are tetrodotoxin insensitive and poorly coordinated among cells, to high-frequency short-duration events that are tetrodotoxin sensitive and tightly coordinated throughout the motor neuron population. This early synchronization may be crucial for correct neuron-target development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.