Evidence map›Paper›PMID 12730341›Full record

Trial reportThe Journal of physiology2003

Baroreflex-mediated changes in cardiac output and vascular conductance in response to alterations in carotid sinus pressure during exercise in humans.

Shigehiko Ogoh, Paul J Fadel, Peter Nissen, Øeivind Jans, Christian Selmer, Niels H Secher, Peter B Raven

Open access · greenAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 154 citations in OpenAlex.

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  20. Baroreflex responses to activity at different temperatures in the South American rattlesnake, Crotalus durissus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shigehiko OgohDepartment of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, TX, USA and Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. sogoh@hsc.unt.edu
Paul J Fadel
Peter Nissen
Øeivind Jans
Christian Selmer
Niels H Secher
Peter B Raven
Rigshospitalet · DKUniversity of North Texas Health Science Center · USUniversity of Copenhagen · DK

Funding

ARTERIAL BAROREFLEX CONTROL OF BLOOD PRESSURE-- EXERCISER01HL045547 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI RAVEN, PETER BERNARD · 1994 to 2006
$2.3M
NHLBI NIH HHS HL-045547NHLBI NIH HHS R01 HL045547
6 · The paper itself

Abstract

We sought to quantify the contribution of cardiac output (Q) and total vascular conductance (TVC) to carotid baroreflex (CBR)-mediated changes in mean arterial pressure (MAP) during mild to heavy exercise. CBR function was determined in eight subjects (25 +/- 1 years) at rest and during three cycle exercise trials at heart rates (HRs) of 90, 120 and 150 beats min-1 performed in random order. Acute changes in carotid sinus transmural pressure were evoked using 5 s pulses of neck pressure (NP) and neck suction (NS) from +40 to -80 Torr (+5.33 to -10.67 kPa). Beat-to-beat changes in HR and MAP were recorded throughout. In addition, stroke volume (SV) was estimated using the Modelflow method, which incorporates a non-linear, three-element model of the aortic input impedance to compute an aortic flow waveform from the arterial pressure wave. The application of NP and NS did not cause any significant changes in SV either at rest or during exercise. Thus, CBR-mediated alterations in Q were solely due to reflex changes in HR. In fact, a decrease in the carotid-HR response range from 26 +/- 7 beats min-1 at rest to 7 +/- 1 beats min-1 during heavy exercise (P = 0.001) reduced the contribution of Q to the CBR-mediated change in MAP. More importantly, at the time of the peak MAP response, the contribution of TVC to the CBR-mediated change in MAP was increased from 74 +/- 14 % at rest to 118 +/- 6 % (P = 0.017) during heavy exercise. Collectively, these findings indicate that alterations in vasomotion are the primary means by which the CBR regulates blood pressure during mild to heavy exercise.

Indexed as

AdultBaroreflexBlood CirculationBlood PressureCardiac OutputCarotid ArteriesCarotid SinusExerciseFemaleHeart RateHumansMaleStroke Volume

Identifiers

PMID12730341
PMCPMC2343007
OpenAlexW1977824667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.