Trial reportThe Journal of physiology2003
Failure of systemic hypoxia to blunt alpha-adrenergic vasoconstriction in the human forearm.
Trial report in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
- β-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia.American journal of physiology. Heart and circulatory physiology · 2025Trial
- Rho-kinase inhibition improves haemodynamic responses and circulating ATP during hypoxia and moderate intensity handgrip exercise in healthy older adults.The Journal of physiology · 2022Trial
- Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation.The Journal of physiology · 2022Trial
- Carotid chemoreceptor modulation of blood flow during exercise in healthy humans.The Journal of physiology · 2011Trial
- Combined inhibition of nitric oxide and vasodilating prostaglandins abolishes forearm vasodilatation to systemic hypoxia in healthy humans.The Journal of physiology · 2011Trial
- Adenosine receptor antagonist and augmented vasodilation during hypoxic exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Trial
- Exercise intensity-dependent contribution of beta-adrenergic receptor-mediated vasodilatation in hypoxic humans.The Journal of physiology · 2008Trial
- Human skeletal muscle sympathetic nerve activity, heart rate and limb haemodynamics with reduced blood oxygenation and exercise.The Journal of physiology · 2003Trial
- Sex-related differences in the peripheral vascular response to hypoxia: Implications in health and relevance for obstructive sleep apnoea.Experimental physiology · 2026Review
- Role of overweight and obesity on vascular responses to the cold pressor test and hypoxia in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Global Reach 2018: sympathetic neural and hemodynamic responses to submaximal exercise in Andeans with and without chronic mountain sickness.American journal of physiology. Heart and circulatory physiology · 2022Article
- Comparisons Between Normobaric Normoxic and Hypoxic Recovery on Post-exercise Hemodynamics After Sprint Interval Cycling in Hypoxia.Frontiers in physiology · 2022Article
- Sympathetic neurovascular transduction following acute hypoxia.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Sex differences in the vascular response to sympathetic activation during acute hypoxaemia.Experimental physiology · 2021Article
- Sex differences in integrated neurocardiovascular control of blood pressure following acute intermittent hypercapnic hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Inhibition of NaThe Journal of physiology · 2018Article
- Impact of Resistance Exercise under Hypoxia on Postexercise Hemodynamics in Healthy Young Males.International journal of hypertension · 2018Article
- Impaired peripheral vasodilation during graded systemic hypoxia in healthy older adults: role of the sympathoadrenal system.American journal of physiology. Heart and circulatory physiology · 2017Article
- Skeletal muscle vasodilation during systemic hypoxia in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Systemic hypoxia in humans evokes forearm vasodilatation despite significant reflex increases in sympathetic vasoconstrictor nerve activity and noradrenaline spillover. We sought to determine whether post-junctional alpha-adrenergic vasoconstrictor responsiveness to endogenous noradrenaline release is blunted during systemic hypoxia. To do so, we conducted a two-part study in healthy young adults. In protocol 1, we measured forearm blood flow (FBF; venous occlusion plethysmography) and calculated the vascular conductance (FVC) responses to brachial artery infusions of two doses of tyramine (evokes endogenous noradrenaline release) in 10 adults during normoxia and mild systemic hypoxia (85 % O2 saturation; pulse oximetry of the earlobe). Systemic hypoxia evoked significant forearm vasodilatation as indicated by the increases in FBF and FVC (approximately 20-23 %; P < 0.05). The low and high doses of tyramine evoked significant reductions in FVC (vasoconstriction) that were similar in magnitude during normoxia (-29 +/- 3 and -53 +/- 4 %) and mild hypoxia (-35 +/- 4 and -58 +/- 3 %; P = 0.33). In protocol 2, forearm vasoconstrictor responses to the high dose of tyramine were determined in eight young adults during normoxia and during graded levels of systemic hypoxia (85, 80 and 75 % O2 saturation). The reductions in FVC were similar during normoxia (-59 +/- 2 %) and the three levels of hypoxia (85 % O2 saturation, -64 +/- 3 %; 80 % O2 saturation, -62 +/- 1 %; 75 % O2 saturation, -61 +/- 3 %; P = 0.37). In both protocols, the tyramine-induced increases in deep venous noradrenaline concentrations were similar during normoxia and all levels of hypoxia. Our results demonstrate that post-junctional alpha-adrenergic receptor vasoconstrictor responsiveness to endogenous noradrenaline release is not blunted during mild-to-moderate systemic hypoxia in healthy humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.