ArticleGenes & development2003
A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A Hitchhiker's guide to RNA-RNA structure and interaction prediction tools.Briefings in bioinformatics · 2023Review
- Predicting structure and stability for RNA complexes with intermolecular loop-loop base-pairing.RNA (New York, N.Y.) · 2014Article
- The genetics of dyskeratosis congenita.Cancer genetics · 2011Review
- Ribonucleoprotein multimers and their functions.Critical reviews in biochemistry and molecular biology · 2010Review
- RNA conformation in catalytically active human telomerase.Journal of the American Chemical Society · 2010Article
- Structural analysis of the catalytic core of human telomerase RNA by FRET and molecular modeling.Biochemistry · 2006Article
- Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain.Molecular and cellular biology · 2006Article
- Regulation of 5' template usage and incorporation of noncognate nucleotides by human telomerase.RNA (New York, N.Y.) · 2005Article
- Functional analysis of the pseudoknot structure in human telomerase RNA.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation.Nucleic acids research · 2005Article
- A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Telomerase dysfunction and dyskeratosis congenita.Cytotechnology · 2004Article
- Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer.Molecular and cellular biology · 2004Article
- Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA.Genes & development · 2004Article
- Telomeres and telomerase.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2004Review
- Tetrahymena telomerase is active as a monomer.Molecular biology of the cell · 2003Article
- Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation.Nucleic acids research · 2003Article
- Comprehensive structure-function analysis of the core domain of human telomerase RNA.Molecular and cellular biology · 2003Article
- A novel pseudoknot element is essential for the action of a yeast telomerase.Genes & development · 2003Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The integral RNA (hTER) of the human telomerase ribonucleoprotein has a conserved secondary structure that contains a potential pseudoknot. Here we examine the role of an intermolecular hTER-hTER interaction in the previously reported functional dimerization of telomerase. We provide evidence that the two conserved, complementary sequences of one stem of the hTER pseudoknot domain can pair intermolecularly in vitro, and that formation of this stem as part of a novel "trans-pseudoknot" is required for telomerase to be active in its dimeric form. Such RNA-RNA interaction mirrors a known property of retroviral reverse transcriptases, which use homodimeric viral genomic RNA substrates.
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