ReviewCurrent diabetes reports2003
Growing evidence for diabetes susceptibility genes from genome scan data.
Review in Current diabetes reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.Diabetes · 2007Pooled it
- Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population.Molecular biology reports · 2014Article
- Article
- Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona Insulin Resistance registry: a focus on Mexican American families in the Southwest.Human heredity · 2014Article
- The Advent of Lifestyle Medicine.Journal of lifestyle medicine · 2013Review
- Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke.PloS one · 2012Article
- Genome-wide linkage analysis of multiple metabolic factors: evidence of genetic heterogeneity.Obesity (Silver Spring, Md.) · 2010Article
- Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.Diabetes/metabolism research and reviews · 2009Article
- Does long-term coffee intake reduce type 2 diabetes mellitus risk?Diabetology & metabolic syndrome · 2009Article
- Finding common susceptibility variants for complex disease: past, present and future.Briefings in functional genomics & proteomics · 2009Review
- Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.European journal of human genetics : EJHG · 2009Article
- Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.Diabetes · 2009Article
- Genome-wide association studies in type 2 diabetes.Current diabetes reports · 2009Review
- Phenotypic and molecular evaluation of a chromosome 1q region with linkage and association to type 2 diabetes in humans.The Journal of clinical endocrinology and metabolism · 2009Article
- Article
- Type 2 diabetes: new genes, new understanding.Trends in genetics : TIG · 2008Review
- Learning from molecular genetics: novel insights arising from the definition of genes for monogenic and type 2 diabetes.Diabetes · 2008Article
- Ordered stratification to reduce heterogeneity in linkage to diabetes-related quantitative traits.Obesity (Silver Spring, Md.) · 2008Article
- Evaluating the association of common PBX1 variants with type 2 diabetes.BMC medical genetics · 2008Article
- The association of PBX1 polymorphisms with overweight/obesity and metabolic alterations in the Korean population.Nutrition research and practice · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide scans for linkage have provided one of the dominant approaches adopted by researchers in their efforts to identify genes responsible for the inherited component of type 2 diabetes susceptibility. Around 20 genome scans have now been completed, in a wide variety of populations. Integration of data from these diverse scans has proven far from trivial, but the contours of genome-wide linkage topography are steadily emerging from the fog of data. Identification of the calpain-10 gene as the probable basis for the chromosome 2q linkage seen in Mexican Americans has provided validation of this positional cloning approach. This report provides an update on recent type 2 diabetes genome scan data, focusing on several chromosomal regions where the evidence for linkage has considerably strengthened in the past year. The current and future value of genome-wide linkage information in the search for type 2 diabetes susceptibility effects is also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.