ArticleGenome research2003
Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymorphism in the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia.Clinical and experimental medicine · 2007Trial
- The role of Wnt pathway in obesity induced inflammation and diabetes: a review.Journal of diabetes and metabolic disorders · 2021Review
- LDkit: a parallel computing toolkit for linkage disequilibrium analysis.BMC bioinformatics · 2020Article
- WNT Signaling in Disease.Cells · 2019Review
- The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus.Archives of endocrinology and metabolism · 2018Article
- A new haplotype block detection method for dense genome sequencing data based on interval graph modeling of clusters of highly correlated SNPs.Bioinformatics (Oxford, England) · 2018Article
- Genome-Wide Association Studies for Pasmo Resistance in Flax (Frontiers in plant science · 2018Article
- Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition.Genomics & informatics · 2016Article
- Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance.Scientific reports · 2016Article
- Haplotype kernel association test as a powerful method to identify chromosomal regions harboring uncommon causal variants.Genetic epidemiology · 2013Article
- The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective.Cell & bioscience · 2012Article
- Similarity-based multimarker association tests for continuous traits.Annals of human genetics · 2012Article
- Characteristics of eight X-STR loci for forensic purposes in the Chinese population.International journal of legal medicine · 2011Article
- The WNT signalling pathway and diabetes mellitus.Diabetologia · 2008Review
- Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Article
- Article
- Article
- Stepwise haplotype analysis: are LD patterns repeatable?Human genomics · 2006Article
- Modeling haplotype block variation using Markov chains.Genetics · 2006Article
Corrections and comments
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Authors and funding
24 authors.
Funding
Abstract
Patterns of linkage disequilibrium (LD) in the human genome are beginning to be characterized, with a paucity of haplotype diversity in "LD blocks," interspersed by apparent "hot spots" of recombination. Previously, we cloned and physically characterized the low-density lipoprotein-receptor-related protein 5 (LRP5) gene. Here, we have extensively analysed both LRP5 and its flanking three genes, spanning 269 kb, for single nucleotide polymorphisms (SNPs), and we present a comprehensive SNP map comprising 95 polymorphisms. Analysis revealed high levels of recombination across LRP5, including a hot-spot region from intron 1 to intron 7 of LRP5, where there are 109 recombinants/Mb (4882 meioses), in contrast to flanking regions of 14.6 recombinants/Mb. This region of high recombination could be delineated into three to four hot spots, one within a 601-bp interval. For LRP5, three haplotype blocks were identified, flanked by the hot spots. Each LD block comprised over 80% common haplotypes, concurring with a previous study of 14 genes that showed that common haplotypes account for at least 80% of all haplotypes. The identification of hot spots in between these LD blocks provides additional evidence that LD blocks are separated by areas of higher recombination.
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