ArticleGenome research2003
Selection on human genes as revealed by comparisons to chimpanzee cDNA.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 146 citations in OpenAlex.
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- Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution.PLoS genetics · 2020Article
- The invasive MED/Q Bemisia tabaci genome: a tale of gene loss and gene gain.BMC genomics · 2018Article
- Single genome retrieval of context-dependent variability in mutation rates for human germline.BMC genomics · 2017Article
- Are Synonymous Sites in Primates and Rodents Functionally Constrained?Journal of molecular evolution · 2016Article
- The functional relevance of somatic synonymous mutations in melanoma and other cancers.Pigment cell & melanoma research · 2015Review
- Gonadal transcriptomics elucidate patterns of adaptive evolution within marine rockfishes (Sebastes).BMC genomics · 2015Article
- Decoding mechanisms by which silent codon changes influence protein biogenesis and function.The international journal of biochemistry & cell biology · 2015Review
- Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
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- Transcriptome analysis of host-associated differentiation in Bemisia tabaci (Hemiptera: Aleyrodidae).Frontiers in physiology · 2014Article
- Synonymous site conservation in the HIV-1 genome.BMC evolutionary biology · 2013Article
- The characteristics and expression profiles of the mitochondrial genome for the Mediterranean species of the Bemisia tabaci complex.BMC genomics · 2013Article
- Sounds of silence: synonymous nucleotides as a key to biological regulation and complexity.Nucleic acids research · 2013Review
- Analysis of a native whitefly transcriptome and its sequence divergence with two invasive whitefly species.BMC genomics · 2012Article
- Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus.BMC genomics · 2012Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To better understand the evolutionary forces that affect human genes, we sequenced 5055 expressed sequence tags from the chimpanzee and compared them to their human counterparts. In conjunction with intergenic chimpanzee DNA sequences and data on human single-nucleotide polymorphisms in the genes studied, this allows us to gauge the extent to which selection affects human genes at a genome-wide scale. The comparison to intergenic DNA sequences indicates that about 39% of silent sites in protein-coding regions are deleterious and subject to negative selection. Further, when the divergence between human and chimpanzee is compared with the extent of nucleotide polymorphisms among humans in the same sequences, there is significantly higher divergence in the 5' untranslated regions (UTRs) but not in other parts of the transcript. This indicates that positive selection may have had a considerable influence on 5'UTRs. The dinucleotide CG (CpG) also exhibits a different substitution pattern within 5'UTRs as compared with other parts of the genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.