ArticleThe Plant cell2003
CLAVATA1 dominant-negative alleles reveal functional overlap between multiple receptor kinases that regulate meristem and organ development.
Article in The Plant cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 189 citations in OpenAlex.
- Ubiquitination of BAM1 attenuates CLE peptide-mediated signaling in the root apical meristem.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Research Progress of CLE and Its Prospects in Woody Plants.Plants (Basel, Switzerland) · 2025Review
- Genome-wide identification and expression analysis of PERK genes in peanut and revelation of bidirectional immune regulatory function.Frontiers in plant science · 2025Article
- CLAVATA3 Signaling Buffers Arabidopsis Shoot Apical Meristem Activity in Response to Photoperiod.International journal of molecular sciences · 2024Article
- TPLATE complex-dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance.EMBO reports · 2023Article
- A network of CLAVATA receptors buffers auxin-dependent meristem maintenance.Nature plants · 2023Article
- PXL1 and SERKs act as receptor-coreceptor complexes for the CLE19 peptide to regulate pollen development.Nature communications · 2023Article
- A novel CLAVATA1 mutation causes multilocularity inPlant direct · 2023Article
- Genetic Diversity of Genes Controlling Unilateral Incompatibility in Japanese Cultivars of Chinese Cabbage.Plants (Basel, Switzerland) · 2021Article
- Increased seed number per silique in Brassica juncea by deleting cis-regulatory region affecting BjCLV1 expression in carpel margin meristem.Plant biotechnology journal · 2021Article
- Genome-Wide Characterization, Evolution, and Expression Analysis of the Leucine-Rich Repeat Receptor-Like Protein Kinase (LRR-RLK) Gene Family inLife (Basel, Switzerland) · 2020Article
- Article
- Genome-Wide Identification and Characterization of theInternational journal of molecular sciences · 2019Article
- EPFL Signals in the Boundary Region of the SAM Restrict Its Size and Promote Leaf Initiation.Plant physiology · 2019Article
- Mutations in the CDS and promoter of BjuA07.CLV1 cause a multilocular trait in Brassica juncea.Scientific reports · 2018Article
- Article
- Knockdown of Rice MicroRNA166 Confers Drought Resistance by Causing Leaf Rolling and Altering Stem Xylem Development.Plant physiology · 2018Article
- Trilocular phenotype in Brassica juncea L. resulted from interruption of CLAVATA1 gene homologue (BjMc1) transcription.Scientific reports · 2017Article
- CLAVATA1 controls distinct signaling outputs that buffer shoot stem cell proliferation through a two-step transcriptional compensation loop.PLoS genetics · 2017Article
- CLE peptide signaling and nitrogen interactions in plant root development.Plant molecular biology · 2016Review
21 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The CLAVATA1 (CLV1) receptor kinase controls stem cell number and differentiation at the Arabidopsis shoot and flower meristems. Other components of the CLV1 signaling pathway include the secreted putative ligand CLV3 and the receptor-like protein CLV2. We report evidence indicating that all intermediate and strong clv1 alleles are dominant negative and likely interfere with the activity of unknown receptor kinase(s) that have functional overlap with CLV1. clv1 dominant-negative alleles show major differences from dominant-negative alleles characterized to date in animal receptor kinase signaling systems, including the lack of a dominant-negative effect of kinase domain truncation and the ability of missense mutations in the extracellular domain to act in a dominant-negative manner. We analyzed chimeric receptor kinases by fusing CLV1 and BRASSINOSTEROID INSENSITIVE1 (BRI1) coding sequences and expressing these in clv1 null backgrounds. Constructs containing the CLV1 extracellular domain and the BRI1 kinase domain were strongly dominant negative in the regulation of meristem development. Furthermore, we show that CLV1 expressed within the pedicel can partially replace the function of the ERECTA receptor kinase. We propose the presence of multiple receptors that regulate meristem development in a functionally related manner whose interactions are driven by the extracellular domains and whose activation requires the kinase domain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.