ArticleMolecular and cellular biology2003
Chromosomal elements regulate gene activity and chromatin structure of the human serpin gene cluster at 14q32.1.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Determinants of transcription factor regulatory range.Nature communications · 2020Article
- Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression.PloS one · 2009Article
- The locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II.Molecular and cellular biology · 2007Article
- Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Formation of a large, complex domain of histone hyperacetylation at human 14q32.1 requires the serpin locus control region.Nucleic acids research · 2005Article
- Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
The human serine protease inhibitor (serpin) gene cluster at 14q32.1 contains a number of genes that are specifically expressed in hepatic cells. Cell-specific enhancers have been identified in several of these genes, but elements involved in locus-wide gene and chromatin control have yet to be defined. To identify regulatory elements in this region, we prepared a series of mutant chromosomal alleles by homologous recombination and transferred the specifically modified human chromosomes to hepatic cells for functional tests. We report that deletion of an 8-kb DNA segment upstream of the human alpha1-antitrypsin gene yields a mutant serpin allele that fails to be activated in hepatic cells. Within this region, a 2.3-kb DNA segment between kb -8.1 and -5.8 contains a previously unrecognized control region that is required not only for serpin gene activation but also for chromatin remodeling of the entire locus.
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Registered trials
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