Evidence map›Paper›PMID 12724060›Full record

ReviewCurrent hypertension reports2003

Brainstem mechanisms of hypertension: role of the rostral ventrolateral medulla.

Alan F Sved, Satoru Ito, Judith C Sved

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 126 citations in OpenAlex.

  1. Article
  2. Single-nucleus RNA sequencing reveals Cntnap2Journal of advanced research · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Clarification of hypertension mechanisms provided by the research of central circulatory regulation.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Neuronal Networks in Hypertension: Recent Advances.Hypertension (Dallas, Tex. : 1979) · 2020
    Review
  13. Subregional differences in GABAThe Journal of comparative neurology · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alan F SvedDepartment of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA. sved@bns.pitt.edu
Satoru Ito
Judith C Sved
University of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The central nervous system plays a key role in the regulation of cardiovascular function, and alterations in the central neural mechanisms that control blood pressure may underlie the vast majority of cases of primary hypertension. The well-studied baroreceptor reflex powerfully regulates arterial pressure, though its involvement in the pathogenesis of chronic hypertension is likely to be only of minor importance. Supraspinal maintenance of sympathetic vasomotor outflow appears to emanate from neurons in the rostral ventrolateral medulla, and the tonic drive exerted on sympathetic vasomotor activity by the rostral ventrolateral medulla appears to be increased in several animal models of hypertension. In particular, the excitation of the rostral ventrolateral medulla by excitatory amino acid neurotransmitters and by stimulation of AT(1) angiotensin receptors appears to be increased in experimental hypertension. The current data support the view that neurogenic hypertension is mediated by increased excitatory drive of rostral ventrolateral medulla sympathoexcitatory neurons.

Indexed as

Angiotensin IIAnimalsBaroreflexBlood PressureHumansHypertensionKynurenic AcidMedulla OblongataMuscarinic AntagonistsNeuronsSignal TransductionSympathetic Nervous SystemAngiotensin IIKynurenic AcidMuscarinic Antagonists

Identifiers

PMID12724060
OpenAlexW1972214265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.