ArticleArthritis research & therapy2003
Osteoclast-independent bone resorption by fibroblast-like cells.
Article in Arthritis research & therapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 65 citations in OpenAlex.
- Effect of cobalt ions on TNF-α and IL-6 secretion by fibroblasts surrounding hip periprosthetic membrane.Frontiers in bioengineering and biotechnology · 2025Article
- Nano wear particles and the periprosthetic microenvironment in aseptic loosening induced osteolysis following joint arthroplasty.Frontiers in cellular and infection microbiology · 2023Review
- Weaving the nest: extracellular matrix roles in pre-metastatic niche formation.Frontiers in oncology · 2023Review
- Dental and Orthopaedic Implant Loosening: Overlap in Gene Expression Regulation.Frontiers in immunology · 2022Article
- Fibroblast-like cells change gene expression of bone remodelling markers in transwell cultures.European journal of medical research · 2020Article
- Osteolytic cancer cells induce vascular/axon guidance processes in the bone/bone marrow stroma.Oncotarget · 2018Article
- Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair.Advanced drug delivery reviews · 2015Review
- Absence of exposed bone following dental extraction in beagle dogs treated with 9 months of high-dose zoledronic acid combined with dexamethasone.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2013Article
- Current imaging strategies in rheumatoid arthritis.American journal of nuclear medicine and molecular imaging · 2012Article
- Growth-associated changes in the periodontal bone and molar teeth of male rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2009Article
- Immune regulation of bone loss by Th17 cells.Arthritis research & therapy · 2008Review
- The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis.Arthritis research & therapy · 2006Article
- Are fibroblasts involved in joint destruction?Annals of the rheumatic diseases · 2005Review
- Metabolic activation stimulates acid secretion and expression of matrix degrading proteases in human osteoblasts.Annals of the rheumatic diseases · 2004Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, mesenchymal cells have only been associated with bone resorption indirectly, and it has been hypothesized that the degradation of bone is associated exclusively with specific functions of osteoclasts. Here we show, in aseptic prosthesis loosening, that aggressive fibroblasts at the bone surface actively contribute to bone resorption and that this is independent of osteoclasts. In two separate models (a severe combined immunodeficient mouse coimplantation model and a dentin pit formation assay), these cells produce signs of bone resorption that are similar to those in early osteoclastic resorption. In an animal model of aseptic prosthesis loosening (i.e. intracranially self-stimulated rats), it is shown that these fibroblasts acquire their ability to degrade bone early on in their differentiation. Upon stimulation, such fibroblasts readily release acidic components that lower the pH of their pericellular milieu. Through the use of specific inhibitors, pericellular acidification is shown to involve the action of vacuolar type ATPases. Although fibroblasts, as mesenchymal derived cells, are thought to be incapable of resorbing bone, the present study provides the first evidence to challenge this widely held belief. It is demonstrated that fibroblast-like cells, under pathological conditions, may not only enhance but also actively contribute to bone resorption. These cells should therefore be considered novel therapeutic targets in the treatment of bone destructive disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.